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Titolo:
A comparison of DNA copy number changes detected by comparative genomic hybridization in malignancies of the liver, biliary tract and pancreas
Autore:
Shiraishi, K; Okita, K; Kusano, N; Harada, T; Kondoh, S; Okita, S; Ryozawa, S; Ohmura, R; Noguchi, T; Iida, Y; Akiyama, T; Oga, A; Fukumoto, Y; Furuya, T; Kawauchi, S; Sasaki, K;
Indirizzi:
Yamaguchi Univ, Sch Med, Dept Pathol, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan Yamaguchi Univ, Sch Med, Dept Internal Med 1, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan Yamaguchi Univ, Sch Med, Dept Gen Practice & Primary Care, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan UBE Cent Hosp, Dept Gastroenterol, Yamaguchi, Japan UBE Cent Hosp Yamaguchi Japan osp, Dept Gastroenterol, Yamaguchi, Japan Shutou Gen Hosp, Dept Internal Med, Yamaguchi, Japan Shutou Gen Hosp Yamaguchi Japan sp, Dept Internal Med, Yamaguchi, Japan Shimonoseki Natl Hosp, Dept Internal Med, Yamaguchi, Japan Shimonoseki Natl Hosp Yamaguchi Japan pt Internal Med, Yamaguchi, Japan Kokura Mem Hosp, Dept Gastroenterol, Fukuoka, Japan Kokura Mem Hosp Fukuoka Japan Hosp, Dept Gastroenterol, Fukuoka, Japan Tenjin Kai Koga Hosp, Dept Gastroenterol, Fukuoka, Japan Tenjin Kai Koga Hosp Fukuoka Japan , Dept Gastroenterol, Fukuoka, Japan
Titolo Testata:
ONCOLOGY
fascicolo: 2, volume: 60, anno: 2001,
pagine: 151 - 161
SICI:
0030-2414(2001)60:2<151:ACODCN>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN HEPATOCELLULAR-CARCINOMA; POLYMERASE CHAIN-REACTION; TUMOR-SUPPRESSOR GENES; SOLID TUMORS; MUTATIONS; ABERRATIONS; ADENOCARCINOMA; CANCERS; AMPLIFICATION; ABNORMALITIES;
Keywords:
comparative genomic hybridization hepatocellular carcinoma; biliary tract cancer; pancreatic cancer; genetic aberrations;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Shiraishi, K Yamaguchi Univ, Sch Med, Dept Pathol, 1-1-1 Minami Kogushi, Ube, Yamaguchi7558505, Japan Yamaguchi Univ 1-1-1 Minami Kogushi Ube Yamaguchi Japan 7558505
Citazione:
K. Shiraishi et al., "A comparison of DNA copy number changes detected by comparative genomic hybridization in malignancies of the liver, biliary tract and pancreas", ONCOL-BASEL, 60(2), 2001, pp. 151-161

Abstract

Tumors arising from the liver, biliary tract and pancreas, which originatein the foregut and are in close anatomical proximity to each other, sometimes show similar histological features. No studies have focused on genetic similarities and differences between tumors of these organs. To elucidate the similarities and differences in DNA copy number alterations between tumors of these organs, we applied comparative genomic hybridization (CGH) to cancers of the liver (31 cases), biliary tract (42 cases) and pancreas (27 cases). Some alterations were common to tumors of all three organs, and somewere preferential in certain types of tumor. Gains of 1q and 8q and lossesof 8p and 17p were common to all tumors. In contrast, 13q14 and 16q losseswere detected exclusively in hepatocellular carcinomas (HCCs; p < 0.01). The incidence of 17q21 gain and 5q loss was higher in biliary tract cancers than in the other two types (p < 0.05). Pancreatic cancers exhibited higherincidence of 5q14-q23 gain and 19p loss than tumors of other organs (p < 0.01). Gains of 7p, 7q, 12p and 20q and losses of 3p, 6q, 9p and 18q were frequent in both biliary tract and pancreatic cancers but rare in HCCs (p < 0.05). The present results suggest that although genes located at 1q, 8p, 8qand 17p are frequently involved in HCC, biliary tract and pancreatic cancer, at least some of the genes implicated in carcinogenesis are different between these three types. It is also suggested that CGH analysis is useful as a potential adjunct for the diagnosis and management of these tumors of organs that are anatomically close to one another. Copyright (C) 2001 S. Karger AG, Basel.

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Documento generato il 04/06/20 alle ore 01:42:09