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Titolo:
In vivo imaging of nicotinic receptor upregulation following chronic (-)-nicotine treatment in baboon using SPECT
Autore:
Kassiou, M; Eberl, S; Meikle, SR; Birrell, A; Constable, C; Fulham, MJ; Wong, DF; Musachio, JL;
Indirizzi:
Royal Prince Alfred Hosp, Dept PET & Nucl Med, Camperdown, NSW 2050, Australia Royal Prince Alfred Hosp Camperdown NSW Australia 2050 SW 2050, Australia Royal Prince Alfred Hosp, Dept Renal Med, Camperdown, NSW 2050, Australia Royal Prince Alfred Hosp Camperdown NSW Australia 2050 SW 2050, Australia Johns Hopkins Med Inst, Dept Radiol, Div Nucl Med, Baltimore, MD 21287 USAJohns Hopkins Med Inst Baltimore MD USA 21287 ed, Baltimore, MD 21287 USA
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 2, volume: 28, anno: 2001,
pagine: 165 - 175
SICI:
0969-8051(200102)28:2<165:IVIONR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; SCATTER CORRECTION METHODS; ACETYLCHOLINE-RECEPTORS; IN-VIVO; RAT-BRAIN; NOISE PROPERTIES; BINDING-SITES; UP-REGULATION; H-3 NICOTINE; MONTE-CARLO;
Keywords:
5-[I-123]-iodo-A-85380; (-)-nicotine; nAChR upregulation; quantitative dynamic SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Kassiou, M Royal Prince Alfred Hosp, Dept PET & Nucl Med, Missenden Rd, Camperdown, NSW 2050, Australia Royal Prince Alfred Hosp Missenden Rd Camperdown NSW Australia 2050
Citazione:
M. Kassiou et al., "In vivo imaging of nicotinic receptor upregulation following chronic (-)-nicotine treatment in baboon using SPECT", NUCL MED BI, 28(2), 2001, pp. 165-175

Abstract

To quantify changes in neuronal nAChR binding in vivo, quantitative dynamic SPECT studies were performed with 5-[I-123]-iodo-A- 85380 in baboons pre and post chronic treatment with (-)-nicotine or saline control. Infusion of(-)-nicotine at a dose of 2.0 mg/kg/24h for 14 days resulted in plasma (-)-nicotine levels of 27.3 ng/mL. This is equivalent to that found in an average human smoker (20 cigarettes a day). In the baboon brain the regional distribution of 5-[I-123]-iodo-A-85380 was consistent with the known densities of nAChRs (thalamus > frontal cortex > cerebellum). Changes in nAChR binding were estimated from the volume of distribution (V-d) and binding potential (BP) derived from 3-compartment model fits. In the (-)-nicotine treatedanimal V-d was significantly increased in the thalamus (52%) and cerebellum (50%) seven days post cessation of (-)-nicotine treatment, suggesting upregulation of nAChRs. The observed 33% increase in the frontal cortex failedto reach significance. A significant increase in BP was seen in the thalamus. In the saline control animal no changes were observed in V-d or BP under any experimental conditions. In this preliminary study, we have demonstrated for the first time in vivo upregulation of neuronal nAChR binding following chronic (-)-nicotine treatment. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:23:17