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Titolo:
Simultaneous evaluation of dual gene transfer to adherent cells by gamma-ray imaging
Autore:
Zinn, KR; Chaudhuri, TR; Buchsbaum, DJ; Mountz, JM; Rogers, BE;
Indirizzi:
Univ Alabama, Dept Radiol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 ept Radiol, Birmingham, AL 35294 USA Univ Alabama, Dept Radiat Oncol, Birmingham, AL USA Univ Alabama Birmingham AL USA ma, Dept Radiat Oncol, Birmingham, AL USA
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 2, volume: 28, anno: 2001,
pagine: 135 - 144
SICI:
0969-8051(200102)28:2<135:SEODGT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; GREEN FLUORESCENT PROTEIN; RECEPTOR-BINDING PEPTIDES; IN-VIVO; REPORTER GENE; ADENOVIRAL VECTOR; LIVING ANIMALS; EXPRESSION; THERAPY; PROLIFERATION;
Keywords:
imaging; gene transfer; somatostatin receptor; thymidine kinase; Tc-99m; I-131;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Zinn, KR Univ Alabama, Dept Radiol, Birmingham, AL 35294 USA Univ AlabamaBirmingham AL USA 35294 l, Birmingham, AL 35294 USA
Citazione:
K.R. Zinn et al., "Simultaneous evaluation of dual gene transfer to adherent cells by gamma-ray imaging", NUCL MED BI, 28(2), 2001, pp. 135-144

Abstract

A gamma camera imaging method was developed to detect dual gene transfer to adherent cells growing as monolayers in cell culture plates. Human cancercells were infected with replication-incompetent adenoviral vectors encoding the human type 2 somatostatin receptor (Ad-hSSTr2) and/or herpes virus thymidine kinase (Ad-TK). The hSSTr2 and TK reporter proteins were detected by imaging internally bound Tc-99m-P2045 peptide (Diatide, Inc.) and radioiodinated 2'-deoxy-2'-fluoro-beta -D-arabinofuranosyl-5-iodouracil (FIAU), respectively. Following gene transfer, expression of hSSTr2 and TK were accurately imaged in vitro. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:19:52