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Titolo:
Characterisation of 3-[I-123]iodo-L-alpha-methyl tyrosine ([I-123]IMT) transport into human Ewing's sarcoma cells in vitro
Autore:
Franzius, C; Kopka, K; van Valen, F; Eckervogt, V; Riemann, B; Sciuk, J; Schober, O;
Indirizzi:
Univ Munster, Dept Nucl Med, D-48149 Munster, Germany Univ Munster Munster Germany D-48149 Nucl Med, D-48149 Munster, Germany Univ Munster, Dept Orthoped, D-48149 Munster, Germany Univ Munster Munster Germany D-48149 Orthoped, D-48149 Munster, Germany
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 2, volume: 28, anno: 2001,
pagine: 123 - 128
SICI:
0969-8051(200102)28:2<123:CO3T(T>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-METHYL-TYROSINE; AMINO-ACID-TRANSPORT; BRAIN-TUMORS; L-3-IODO-ALPHA-METHYL TYROSINE; GLIOMA; EXPRESSION; CANCER; SPECT; LINE; PET;
Keywords:
3-[I-123]iodo-L-alpha-methyl tyrosine; Ewing's sarcoma; transport kinetics; system L;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Franzius, C Univ Munster, Dept Nucl Med, Albert Schweitzer Str 33, D-48149Munster, Germany Univ Munster Albert Schweitzer Str 33 Munster Germany D-48149
Citazione:
C. Franzius et al., "Characterisation of 3-[I-123]iodo-L-alpha-methyl tyrosine ([I-123]IMT) transport into human Ewing's sarcoma cells in vitro", NUCL MED BI, 28(2), 2001, pp. 123-128

Abstract

3-[I-123]Iodo-L-alpha -methyl tyrosine ([I-123]IMT) scintigraphy of extracranial malignant tumors has been described, but Little is known about the transport systems involved in [I-123]IMT uptake into extracranial tumor cells. Here, the precise kinetics of [I-123]IMT transport into human Ewing's sarcoma cells (VH-64) was determined. The apparent Michaelis constant was of high affinity value (K-m = 41.7 +/- 3.9 muM) and maximum transport velocitiy amounted to V-max = 20.7 +/- 0.6 nmol . mg protein(-1) .10 min(-1). Inhibition experiments revealed the predominance of [I-123]IMT uptake via sodium-independent system L. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 23:32:52