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Titolo:
Integrity of the blood-cerebrospinal fluid barrier in early Parkinson's disease
Autore:
Haussermann, P; Kuhn, W; Przuntek, H; Muller, T;
Indirizzi:
Tech Univ Munich, Klinikum Rechts Isar, Dept Neurol, D-8000 Munich, Germany Tech Univ Munich Munich Germany D-8000 pt Neurol, D-8000 Munich, Germany Ruhr Univ Bochum, St Josef Hosp, D-4630 Bochum, Germany Ruhr Univ Bochum Bochum Germany D-4630 osef Hosp, D-4630 Bochum, Germany
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 300, anno: 2001,
pagine: 182 - 184
SICI:
0304-3940(20010316)300:3<182:IOTBFB>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-BARRIER; IGG; DYSFUNCTION; PHYSIOLOGY; ALZHEIMERS; DISORDERS; DEMENTIA; ALBUMIN;
Keywords:
blood-blood-cerebrospinal fluid barrier; Parkinson's disease; cerebrospinal fluid; albumin; IgG cerebrospinal fluid/serum ratios; humoral immune response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Haussermann, P Tech Univ Munich, Klinikum Rechts Isar, Dept Neurol, D-8000Munich, Germany Tech Univ Munich Munich Germany D-8000 00 Munich, Germany
Citazione:
P. Haussermann et al., "Integrity of the blood-cerebrospinal fluid barrier in early Parkinson's disease", NEUROSCI L, 300(3), 2001, pp. 182-184

Abstract

Dysfunction of the blood-cerebrospinal fluid barrier (BCB) has been implicated in the pathogenesis of Parkinson's disease (PD) and other neurodegenerative disorders. Therefore, we assayed serum and cerebrospinal fluid (CSF) from 30 parkinsonian patients and 30 controls for concentrations of albuminand IgG. The CSF/serum ratio for albumin (AQ), IgG (GQ), IgG-index as wellas determination of oligoclonal bands were used to evaluate BCB function and to quantify humoral immune response within the central nervous system (CNS). Levels of AQ, GQ and IgG-index did not significantly differ in both groups. We found no dysfunction of the blood-CSF barrier or signs of local synthesis of IgG in the central nervous system of parkinsonian patients. Our data do not support the hypothesis of a dysfunctional BCB that contributes to pathophysiological mechanisms underlying PD. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 17:37:56