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Titolo:
m-Chlorophenylpiperazine excites non-dopaminergic neurons in the rat substantia nigra and ventral tegmental area by activating serotonin-2C receptors
Autore:
Di Giovanni, G; Di Matteo, V; La Grutta, V; Esposito, E;
Indirizzi:
Ist Ric Farmacol Mario Negri, Consorzio Mario Negri Sud, I-66030 Santa Maria Imbaro, Chieti, Italy Ist Ric Farmacol Mario Negri Santa Maria Imbaro Chieti Italy I-66030 taly Univ Palermo, Ist Fisiol Umana G Pagano, I-90134 Palermo, Italy Univ Palermo Palermo Italy I-90134 mana G Pagano, I-90134 Palermo, Italy
Titolo Testata:
NEUROSCIENCE
fascicolo: 1, volume: 103, anno: 2001,
pagine: 111 - 116
SICI:
0306-4522(2001)103:1<111:MENNIT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARS RETICULATA NEURONS; IN-VIVO; EXCITATION; TERMINALS; SYSTEM; GABA;
Keywords:
GABAergic neurons; zona reticulata; ventral tegmental area; 5-HT2C receptors; interneurons; electrophysiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Esposito, E Ist Ric Farmacol Mario Negri, Consorzio Mario Negri Sud, I-66030 Santa Maria Imbaro, Chieti, Italy Ist Ric Farmacol Mario Negri Santa Maria Imbaro Chieti Italy I-66030
Citazione:
G. Di Giovanni et al., "m-Chlorophenylpiperazine excites non-dopaminergic neurons in the rat substantia nigra and ventral tegmental area by activating serotonin-2C receptors", NEUROSCIENC, 103(1), 2001, pp. 111-116

Abstract

In vivo electrophysiological techniques were used to study the effect of m-chlorophenylpiperazine, a non-selective serotonin-2C receptor agonist, on the activity of non-dopaminergic neurons in the substantia nigra pars reticulata and the ventral tegmental area of anesthetized rats. Intravenous administration of m-chlorophenylpiperazine (5-320 mug/kg) caused a dose-dependent increase in the basal firing rate of a subpopulation of nigral neurons which do not respond to a footpinch stimulus [P(0) neurons], whereas it did not affect the activity of neurons which are responsive to the footpinch [P(+) neurons]. However. m-chlorophenylpiperazine (5-320 mug/kg) excited all non-dopaminergic neurons sampled in the ventral tegmental area. Moreover, microiontophoretic application of m-chlorophenylpiperazine (10-40 nA) causedan excitation of P(0) nigral and ventral tegmental area neurons. Pretreatment with the selective serotonin-2C receptor antagonist SE 242084 (200 mug/kg, i.v.) completely blocked the excitatory effect of i.v. m-chlorophenylpiperazine (5-320 mug/kg), both in the substantia nigra pars reticulata and in the ventral tegmental area. It is concluded that stimulation of serotonin-2C receptors by m-chlorophenylpiperazine activates non-dopaminergic (presumably GABA-containing) neurons in the substantia nigra pars reticulata and ventral tegmental area. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:20:44