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Titolo:
Progressive visual sensitivity loss in the Royal College of Surgeons rat: Perimetric study in the superior colliculus
Autore:
Sauve, Y; Girman, SV; Wang, S; Lawrence, JM; Lund, RD;
Indirizzi:
UCL, Inst Ophthalmol, Dept Pathol, Neural Transplant Program, London EC1V 9EL, England UCL London England EC1V 9EL Transplant Program, London EC1V 9EL, England Russian Acad Sci, Inst Dev Biol, Moscow 117808, Russia Russian Acad Sci Moscow Russia 117808 st Dev Biol, Moscow 117808, Russia
Titolo Testata:
NEUROSCIENCE
fascicolo: 1, volume: 103, anno: 2001,
pagine: 51 - 63
SICI:
0306-4522(2001)103:1<51:PVSLIT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHERITED RETINAL DYSTROPHY; RESCUES PHOTORECEPTOR CELLS; FIBROBLAST-GROWTH-FACTOR; PUPILLARY LIGHT REFLEX; RCS RATS; RETINITIS-PIGMENTOSA; GANGLION-CELLS; DARK-ADAPTATION; DEGENERATION; EPITHELIUM;
Keywords:
retinal degeneration; superior colliculus; electrophysiology; visual field; perimetry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Sauve, Y UCL, Inst Ophthalmol, Dept Pathol, Neural Transplant Program, 11-43 Bath St, London EC1V 9EL, England UCL 11-43 Bath St London England EC1V9EL ndon EC1V 9EL, England
Citazione:
Y. Sauve et al., "Progressive visual sensitivity loss in the Royal College of Surgeons rat: Perimetric study in the superior colliculus", NEUROSCIENC, 103(1), 2001, pp. 51-63

Abstract

The Royal College of Surgeons rat has a retinal pigment epithelial cell defect which causes a progressive loss of rods occurring primarily over the first few months of life. We have studied the consequences of this degenerative process on visual sensitivity across the visual field. Sensitivities were determined in the superior colliculus for unit responses recorded from 22 days up to one year of age from sites encompassing the whole visual fieldrepresentation. Following visual sensitivity assessment, retinae were examined anatomically at the light and electron microscopic level. At 22 days of age, sensitivities in dystrophic rats were comparable to those of non-dystrophies at any age (40 +/- 1 and 41 +/- 1 dB. respectively), despite the fact that signs of degenerative events were clear at the electron microscopic level, including presence of pyknotic photoreceptor nuclei, disorganised outer segments and accumulation of debris. However, loss in sensitivity wasfirst detected only at 28-36 days of age (27 +/- 4 dB). From then on, sensitivities progressively decreased to reach a plateau by 180-240 days (4 +/-2 dB). Starring around 90 days and onward, there was a positive gradient of sensitivities from temporal to nasal field. Drops in visual sensitivity were parallelled by several changes in visual response properties, includingprolonged latency, inconsistent responsiveness, appearance of bursting spontaneous activity and activation of units by stimuli presented outside their classical receptive fields. The measure of visual sensitivities by recording visual responses at specific sites in the superior colliculus provides a reliable point-to-point assessment of retinal function comparable to visual perimetry testing in humans. This experimental approach provides the background for answering questions arising during the development of potential experimental therapies for retinal degeneration using animal models like the Royal College of Surgeons rat. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:18:56