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Titolo:
Studies on [H-3]CP-55940 binding in the human central nervous system: Regional specific changes in density of cannabinoid-1 receptors associated withschizophrenia and cannabis use
Autore:
Dean, B; Sundram, S; Bradbury, R; Scarr, E; Copolov, D;
Indirizzi:
Mental Hlth Res Inst Victoria, Rebecca L Cooper Res Labs, Parkville, Vic 3052, Australia Mental Hlth Res Inst Victoria Parkville Vic Australia 3052 052, Australia Univ Melbourne, Dept Psychiat, Parkville, Vic 3052, Australia Univ Melbourne Parkville Vic Australia 3052 arkville, Vic 3052, Australia
Titolo Testata:
NEUROSCIENCE
fascicolo: 1, volume: 103, anno: 2001,
pagine: 9 - 15
SICI:
0306-4522(2001)103:1<9:SO[BIT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BRAIN; MARIHUANA; TIME;
Keywords:
cannabinoid-1 receptor; postmortem; human brain; dorsolateral prefrontal cortex; hippocampus; caudate-putamen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Dean, B Mental Hlth Res Inst Victoria, Rebecca L Cooper Res Labs, Locked Bag 11, Parkville, Vic 3052, Australia Mental Hlth Res Inst Victoria Locked Bag 11 Parkville Vic Australia 3052
Citazione:
B. Dean et al., "Studies on [H-3]CP-55940 binding in the human central nervous system: Regional specific changes in density of cannabinoid-1 receptors associated withschizophrenia and cannabis use", NEUROSCIENC, 103(1), 2001, pp. 9-15

Abstract

A number of studies suggested that cannabis use can cause or exacerbate psychoses and may increase the risk of developing schizophrenia, These findings suggest that changes in the cannabinoid system of the brain may be involved in the pathology of schizophrenia. To determine whether changes in the cannabinoid system were present in the brains of subjects with schizophrenia, we used in situ radioligand binding and autoradiography to measure the binding of [H-3]CP-55940 to the cannabinoid-1 receptor in the dorsolateral prefrontal cortex (Brodmann's area 9), caudate-putamen and areas of the temporal lobe from schizophrenic and control subjects, some of whom had ingested cannabis close to death. There was an increase in the density of [H-3]CP-55940 binding to cannabinoid-1 receptors in the dorsolateral prefrontal cortex from subjects with schizophrenia (mean +/- S.E.M.: 142 +/- 9.9 vs 119 +/- 6.6 fmol/mg estimated tissue equivalents: P < 0.05) that was independentof recent cannabis ingestion. There was an increase in the density of cannabinoid-1 receptors in the caudate-putamen from subjects who had recently ingested cannabis (151 +/- 9.0 vs 123 +/- 7.2 fmol/mg estimated tissue equivalents: P < 0.05) that was independent of diagnoses. These data indicate that there are changes in cannabinoid-1 receptors in the dorsolateral prefrontal cortex that may prove to he associated with the pathology of schizophrenia. By contrast. changes in the density of cannabinoid-1 receptors may occur in the caudate-putamen in response to cannabis ingestion. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:26:41