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Titolo:
Absence of the adenosine A(2A) receptor or its chronic blockade decrease ethanol withdrawal-induced seizures in mice
Autore:
El Yacoubi, M; Ledent, C; Parmentier, M; Daoust, M; Costentin, J; Vaugeois, JM;
Indirizzi:
Fac Med & Pharm, IFRMP 23, Unite Neuropsychopharmacol Expt, UPRESA CNRS 6036, F-76183 Rouen, France Fac Med & Pharm Rouen France F-76183 SA CNRS 6036, F-76183 Rouen, France Free Univ Brussels, IRIBHN, B-1070 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1070 BHN, B-1070 Brussels, Belgium UFR Pharm, Physiol Lab, F-80037 Amiens, France UFR Pharm Amiens France F-80037 arm, Physiol Lab, F-80037 Amiens, France
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 3, volume: 40, anno: 2001,
pagine: 424 - 432
SICI:
0028-3908(200103)40:3<424:AOTAAR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT CEREBRAL-CORTEX; AMINO-ACID RELEASE; ACETYLCHOLINE-RELEASE; ALCOHOL-WITHDRAWAL; EXTRACELLULAR GLUTAMATE; NERVE-TERMINALS; IN-VITRO; DOPAMINE; MOUSE; HIPPOCAMPUS;
Keywords:
adenosine A(2A) receptor; seizure; adenosine A(2A) receptor knockout mice; ethanol withdrawal; ZM 241385;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Vaugeois, JM Fac Med & Pharm, IFRMP 23, Unite Neuropsychopharmacol Expt, UPRESA CNRS 6036, 22 Blvd Gambetta, F-76183 Rouen, France Fac Med & Pharm 22Blvd Gambetta Rouen France F-76183 France
Citazione:
M. El Yacoubi et al., "Absence of the adenosine A(2A) receptor or its chronic blockade decrease ethanol withdrawal-induced seizures in mice", NEUROPHARM, 40(3), 2001, pp. 424-432

Abstract

Considering the existing interactions between ethanol and adenosine, the influence of the genetic impairment of the adenosine A(2A) receptor has beenexamined upon the seizures occurring at the cessation of chronic ethanol intake or 'ethanol withdrawal' in male mice. Acute clearance of ethanol did not differ between adenosine A(2A) receptor knockout and wild-type mice. Mice were exposed for 10 days to a diet consisting of a milky chocolate drinkthat contained increasing concentrations (1.8, 3.6 and 6.3% V/V) Of ethanol. Adenosine A(2A) receptor knockout mice ingested similar amounts of the fluid, either containing alcohol or not, as did the controls. The severity of handling-induced convulsions during withdrawal was significantly reduced in the adenosine A(2A) receptor knockout mice as compared with their wild-type controls. The selective adenosine A(2A) receptor antagonist ZM 241385 (20 mg/kg) also significantly attenuated the intensity of withdrawal-inducedseizures occurring in wild-type male mice when intraperitoneally administered twice daily during the last 5 days of the forced alcohol intake. These results suggest that selective adenosine A(2A) receptor antagonists may be useful in the treatment of alcohol withdrawal. (C) 2001 Elsevier Science Ltd. All rights reserved.

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Documento generato il 28/03/20 alle ore 23:14:48