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Titolo:
Double activity imaging reveals distinct cellular targets of haloperidol, clozapine and dopamine D-3 receptor selective RGH-1756
Autore:
Kovacs, KJ; Csejtei, M; Laszlovszky, I;
Indirizzi:
Gedeon Richter Ltd, Mol Pharmacol Lab, H-1475 Budapest 10, Hungary Gedeon Richter Ltd Budapest Hungary 10 Lab, H-1475 Budapest 10, Hungary Hungarian Acad Sci, Inst Expt Med, Lab Mol Neuroendocrinol, Budapest, Hungary Hungarian Acad Sci Budapest Hungary Neuroendocrinol, Budapest, Hungary
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 3, volume: 40, anno: 2001,
pagine: 383 - 393
SICI:
0028-3908(200103)40:3<383:DAIRDC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMEDIATE-EARLY GENES; C-FOS EXPRESSION; NERVOUS-SYSTEM; MESSENGER-RNA; RAT-BRAIN; TRANSCRIPTION FACTORS; INSITU HYBRIDIZATION; NUCLEUS-ACCUMBENS; PROTO-ONCOGENE; VISUAL-CORTEX;
Keywords:
c-Fos; haloperidol; clozapine; RGH-1756; major island of Callejal; nucleus accumbens;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Laszlovszky, I Gedeon Richter Ltd, Mol Pharmacol Lab, POB 27, H-1475 Budapest 10, Hungary Gedeon Richter Ltd POB 27 Budapest Hungary 10 10, Hungary
Citazione:
K.J. Kovacs et al., "Double activity imaging reveals distinct cellular targets of haloperidol, clozapine and dopamine D-3 receptor selective RGH-1756", NEUROPHARM, 40(3), 2001, pp. 383-393

Abstract

Acute administration of typical (haloperidol) and atypical (clozapine) antipsychotics results in distinct and overlapping regions of immediate-early gene expression in the rat brain. RGH-1756 is a recently developed atypicalantipsychotic with high affinity to dopamine D-3 receptors that results ina unique pattern of c-Fos induction. A single injection of either antipsychotic results in c-fos mRNA expression that peaks around 30 min after drug administration, while the maximum of c-Fos protein induction is seen 2 h after challenge. The transient and distinct temporal inducibility of c-fos mRNA and c-Fos protein was exploited to reveal and compare cellular targets of different antipsychotic drugs by concomitant localization of r-fos mRNA and c-Fos immunoreactivity in brain sections of rats that were timely challenged with two different antipsychotics. Double activity imaging revealed that haloperidol, clozapine and RGH-1756 share cellular targets in the nucleus accumbens, where 40% of all labeled neurons displayed both c-fos mRNA andc-Fos protein. Haloperidol activates cells in the caudate putamen, while clozapine-responsive, single labeled neurons were dominant in the prefrontalcortex and major island of Calleja. RGH-1756 targets haloperidol-sensitivecells in the caudate putamen, but cells that are activated by clozapine and RGH-1756 in the major island of Calleja are different. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 23:19:54