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Titolo:
Occipital hypoperfusion on SPECT in dementia with Lewy bodies but not AD
Autore:
Lobotesis, K; Fenwick, JD; Phipps, A; Ryman, A; Swann, A; Ballard, C; McKeith, IG; OBrien, JT;
Indirizzi:
Newcastle Gen Hosp, Inst Hlth Elderly, Wolfson Res Ctr, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England Newcastle Gen Hosp Newcastle Upon Tyne Tyne & Wear England NE4 6BE ngland Newcastle Gen Hosp, Dept Reg Med Phys, Newcastle Upon Tyne NE4 6BE, Tyne &Wear, England Newcastle Gen Hosp Newcastle Upon Tyne Tyne & Wear England NE4 6BE ngland
Titolo Testata:
NEUROLOGY
fascicolo: 5, volume: 56, anno: 2001,
pagine: 643 - 649
SICI:
0028-3878(20010313)56:5<643:OHOSID>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
WHITE-MATTER LESIONS; CEREBRAL BLOOD-FLOW; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; VASCULAR DEMENTIA; BODY-DEMENTIA; GLUCOSE HYPOMETABOLISM; VISUAL HALLUCINATIONS; TC-99M-HMPAO SPECT; SENILE DEMENTIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: O'Brien, JT Newcastle Gen Hosp, Inst Hlth Elderly, Wolfson Res Ctr, Westgate Rd, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England Newcastle Gen HospWestgate Rd Newcastle Upon Tyne Tyne & Wear England NE4 6BE
Citazione:
K. Lobotesis et al., "Occipital hypoperfusion on SPECT in dementia with Lewy bodies but not AD", NEUROLOGY, 56(5), 2001, pp. 643-649

Abstract

Objective: To compare regional cerebral blood flow (rCBF) changes using Tc-99m-hexamethylpropyleneamine oxime (Tc-99m-HMPAO) SPECT in subjects with dementia with Lewy bodies (DLB) and AD and in normal age-matched control subjects; to examine the utility of SPECT changes in the differential diagnosis of AD and DLB. Method: Whole-brain SPECT scans were acquired using a single-headed rotating gamma camera (IGE CamStar XR/T) in elderly subjects withconsensus criteria DLB (n = 23; mean age = 79.4 years), National Instituteof Neurological and Communicative Disorders and Stroke-Alzheimer's Diseaseand Related Disorders Association AD (n = 50; 81.9 years), and normal control subjects (n = 20; 78.1 years) after injection with 500 MBq of Tc-99m-HMPAO. Region-of-interest analysis was performed using a SPECT template registered in Talairach space, with rCBF normalized to cerebellum. Results: BothDLB and AD subjects had significantly reduced rCBF in parietal and temporal regions compared with the control subjects. The AD group also showed a significant reduction in rCBF in the frontal and medial temporal regions and the DLB in the occipital areas compared with control subjects. AD and DLB groups differed only in occipital perfusion (p < 0.01). SPECT measures (occipital and medial temporal) correctly classified 69% of all subjects, with a65% sensitivity and 87% specificity for DLB against AD and control subjects. Conclusion: Temporoparietal hypoperfusion on SPECT is common to both AD and DLB. Occipital hypoperfusion is more frequently seen in DLB. Although not diagnostically specific in individual cases, occipital hypoperfusion on SPECT should raise suspicion that DLB may be the cause of dementia, prompting careful search for other features of the disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:58:40