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Titolo:
Themes and variations on ubiquitylation
Autore:
Weissman, AM;
Indirizzi:
NCI, Canc Res Ctr, Lab Immune Cell Biol, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 r, Lab Immune Cell Biol, Bethesda, MD 20892 USA
Titolo Testata:
NATURE REVIEWS MOLECULAR CELL BIOLOGY
fascicolo: 3, volume: 2, anno: 2001,
pagine: 169 - 178
SICI:
1471-0072(200103)2:3<169:TAVOU>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
UBIQUITIN-PROTEIN LIGASE; ANAPHASE-PROMOTING COMPLEX; TUMOR-SUPPRESSOR PROTEIN; KAPPA-B-ALPHA; GROWTH-FACTOR RECEPTOR; RING FINGER PROTEINS; MULTIUBIQUITIN-CHAIN; ACTIVATING ENZYME; DNA-REPAIR; SACCHAROMYCES-CEREVISIAE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
107
Recensione:
Indirizzi per estratti:
Indirizzo: Weissman, AM NCI, Canc Res Ctr, Lab Immune Cell Biol, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 Cell Biol, Bethesda, MD 20892 USA
Citazione:
A.M. Weissman, "Themes and variations on ubiquitylation", NAT REV MOL, 2(3), 2001, pp. 169-178

Abstract

Ubiquitylation - the conjugation of proteins with a small protein called ubiquitin - touches upon all aspects of eukaryotic biology, and its defective regulation is manifest in diseases that range from developmental abnormalities and autoimmunity to neurodegenerative diseases and cancer. A few years ago, we could only have dreamt of the complex arsenal of enzymes dedicated to ubiquitylation. Why has nature come up with so many ways of doing whatseems to be such a simple job?.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 04:13:12