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Titolo:
B7-H3: A costimulatory molecule for T cell activation and IFN-gamma production
Autore:
Chapoval, AI; Ni, J; Lau, JS; Wilcox, RA; Flies, DB; Liu, D; Dong, HD; Sica, GL; Zhu, GF; Tamada, K; Chen, LP;
Indirizzi:
Mayo Clin & Mayo Fdn, Mayo Grad Sch, Dept Immunol, Rochester, MN 55905 USAMayo Clin & Mayo Fdn Rochester MN USA 55905 unol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Mayo Med Sch, Dept Immunol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 unol, Rochester, MN 55905 USA Human Genome Sci Inc, Rockville, MD 20850 USA Human Genome Sci Inc Rockville MD USA 20850 Inc, Rockville, MD 20850 USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 3, volume: 2, anno: 2001,
pagine: 269 - 274
SICI:
1529-2908(200103)2:3<269:BACMFT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
B7 FAMILY; CO-STIMULATION; TNF-ALPHA; RECEPTOR; LIGAND; ICOS; EXPRESSION; ENGAGEMENT; MEMBER; CTLA-4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, LP Mayo Clin & Mayo Fdn, Mayo Grad Sch, Dept Immunol, 200 1st St SW,Rochester, MN 55905 USA Mayo Clin & Mayo Fdn 200 1st St SW Rochester MN USA 55905 905 USA
Citazione:
A.I. Chapoval et al., "B7-H3: A costimulatory molecule for T cell activation and IFN-gamma production", NAT IMMUNOL, 2(3), 2001, pp. 269-274

Abstract

We describe here a newly identified member of the human B7 family, designated B7 homolog 3 (B7-H3), that shares 20-27% amino acid identity with otherB7 family members, B7-H3 mRNA is not detectable in peripheral blood mononuclear cells, although it is found in various normal tissues and in several tumor cell lines. Expression of B7-H3 protein, however, can be induced on dendritic cells (DCs) and monocytes by inflammatory cytokines and a combination of phorbol myristate acetate (PMA) + ionomycin, Soluble B7-H3 protein binds a putative counter-receptor on activated T cells that is distinct fromCD28, cytotoxic T lymphocyte antigen 4 (CTLA-4), inducible costimulator (ICOS) and PD-1. B7-H3 costimulates proliferation of both CD4(+) and CD8(+) Tcells, enhances the induction of cytotoxic T cells and selectively stimulates interferon gamma (IFN-gamma) production in the presence of T cell receptor signaling. In contrast, inclusion of antisense B7-H3 oligonucleotides decreases the expression of B7-H3 on DCs and inhibits IFN-gamma production by DC-stimutated allogeneic T cells. Thus, we describe a newly identified costimulatory pathway that may participate in the regulation of cell-mediatedimmune responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:46:12