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Titolo:
Costimulation of CD8 alpha beta T cells by NKG2D via engagement by MIC induced on virus-infected cells
Autore:
Groh, V; Rhinehart, R; Randolph-Habecker, J; Topp, MS; Riddell, SR; Spies, T;
Indirizzi:
Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98109 , Seattle, WA 98109 USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 3, volume: 2, anno: 2001,
pagine: 255 - 260
SICI:
1529-2908(200103)2:3<255:COCABT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; NK CELLS; INHIBITORY RECEPTORS; HUMAN CYTOMEGALOVIRUS; PROTEIN PP65; IN-VIVO; ANTIGEN; ACTIVATION; LYMPHOCYTES; CLONES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Groh, V Fred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave N, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr 1100 Fairview Ave N Seattle WA USA 98109
Citazione:
V. Groh et al., "Costimulation of CD8 alpha beta T cells by NKG2D via engagement by MIC induced on virus-infected cells", NAT IMMUNOL, 2(3), 2001, pp. 255-260

Abstract

NKG2D is an activating receptor that stimulates innate immune responses bynatural killer cells upon engagement by MIC ligands, which are induced by cellular stress. Because NKG2D is also present on most CD8 alpha beta T cells, it may modulate antigen-specific T cell responses, depending on whetherMIC molecules-distant homologs of major histocompatibility complex (MHC) class I with no function in antigen presentation-are induced on the surface of pathogen-infected cells. We found that infection by cytomegalovirus (CMV) resulted in substantial increases in MIC on cultured fibroblast and endothelial cells and was associated with induced MIC expression in interstitialpneumonia, MIC engagement of NKG2D potently augmented T cell antigen receptor (TCR)-dependent cytolytic and cytokine responses by CMV-specific CD28(-) CD8 alpha beta T cells. This function overcame viral interference with MHC class I antigen presentation. Combined triggering of TCR-CD3 complexes and NKG2D induced interleukin 2 production and T cell proliferation. Thus NKG2D functioned as a costimulatory receptor that can substitute for CD28.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 02:18:18