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Titolo:
An unexpected version of horror autotoxicus: anaphylactic shock to a self peptide
Autore:
Pedotti, R; Mitchell, D; Wedemeyer, J; Karpuj, M; Chabas, D; Hattab, EM; Tsai, M; Galli, SJ; Steinman, L;
Indirizzi:
Stanford Univ, Med Ctr, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 & Neurol Sci, Stanford, CA 94305 USA Stanford Univ, Med Ctr, Dept Pathol, Stanford, CA 94305 USA Stanford UnivStanford CA USA 94305 , Dept Pathol, Stanford, CA 94305 USA Univ Milan, IRCCS Osped Maggiore Policlin, Inst Clin Neurol, Milan, Italy Univ Milan Milan Italy aggiore Policlin, Inst Clin Neurol, Milan, Italy
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 3, volume: 2, anno: 2001,
pagine: 216 - 222
SICI:
1529-2908(200103)2:3<216:AUVOHA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELIN BASIC-PROTEIN; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MAST-CELL DEGRANULATION; CENTRAL-NERVOUS-SYSTEM; TUMOR-NECROSIS-FACTOR; FC-GAMMA-RIII; MULTIPLE-SCLEROSIS; T-CELLS; PROTEOLIPID PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Steinman, L Stanford Univ, Med Ctr, Dept Neurol & Neurol Sci, Stanford, CA94305 USA Stanford Univ Stanford CA USA 94305 i, Stanford, CA 94305 USA
Citazione:
R. Pedotti et al., "An unexpected version of horror autotoxicus: anaphylactic shock to a self peptide", NAT IMMUNOL, 2(3), 2001, pp. 216-222

Abstract

EAE can refer either to experimental autoimmune encephalomyelitis or experimental allergic encephalomyelitis. Although EAE is classically a prototypicT helper I (THI) cell-mediated autoimmune disease, it can also be induced by T(H)2 cells. Characteristically, the most severe manifestation of allergy, anaphylaxis, is associated with exposure to a foreign antigen that is often derived from medication, insect venom or food. We report here that, after self-tolerance to myelin is destroyed, anaphylaxis may be triggered by aself-antigen, in this case a myelin peptide. "Horror autotoxicus", which was initially described by Ehrlich, may not only include autoimmunity to self, it may also encompass immediate hypersensitivity to self, which leads toshock and rapid death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/20 alle ore 10:21:08