Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Activation of Ty transposition by mutagens
Autore:
Staleva, LS; Venkov, P;
Indirizzi:
NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USA NYU New York NY USA 10016 Sch Med, Dept Cell Biol, New York, NY 10016 USA Bulgarian Acad Sci, Inst Mol Biol, BU-1113 Sofia, Bulgaria Bulgarian Acad Sci Sofia Bulgaria BU-1113 Biol, BU-1113 Sofia, Bulgaria
Titolo Testata:
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
fascicolo: 1-2, volume: 474, anno: 2001,
pagine: 93 - 103
SICI:
1386-1964(20010301)474:1-2<93:AOTTBM>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
DAMAGE-INDUCIBLE GENE; DOUBLE-STRAND BREAKS; CELL-CYCLE ARREST; DNA-DAMAGE; SACCHAROMYCES-CEREVISIAE; RESPONSIVE ELEMENT; SEQUENCE-ANALYSIS; RAD9 CHECKPOINT; YEAST; RETROTRANSPOSITION;
Keywords:
mutagenicity assay; S. cerevisiae; yeast; Ty1 retrotransposition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Staleva, LS NYU, Sch Med, Dept Cell Biol, Room 698,550 1st Ave, New York, NY 10016 USA NYU Room 698,550 1st Ave New York NY USA 10016 k, NY 10016 USA
Citazione:
L.S. Staleva e P. Venkov, "Activation of Ty transposition by mutagens", MUT RES-F M, 474(1-2), 2001, pp. 93-103

Abstract

The induction of Ty1 transposition by mutagens (MMS and 4NQO) in asynchronous cultures and cells blocked in G1 and G2/M suggested G1 dependence of activation of Ty1 element by DNA damage. Northern blot analysis revealed immediate five-fold increase in levels of Ty1 transcript after 20 min incubation of cells with 1 mug/ml 4NQO and four-fold increase in Ty1 RNA after treatment the cells with 0.1% MMS. Western blot analysis showed no difference inTyA protein in treated and untreated with mutagen cells. Quantitative mutagenicity assay and Northern blot analysis demonstrated dependence of induction of Ty1 element by DNA-damaging agents on the function of RAD9 gene and independence on DUN1 gene. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:32:54