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Titolo:
Salsolinol, a naturally occurring tetrahydroisoquinoline alkaloid, inducesDNA damage and chromosomal aberrations in cultured Chinese hamster lung fibroblast cells
Autore:
Jung, YJ; Youn, JY; Ryu, JC; Surh, YJ;
Indirizzi:
Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea Seoul Natl Univ Seoul South Korea 151742 harm, Seoul 151742, South Korea Korea Inst Sci & Technol, Seoul 130650, South Korea Korea Inst Sci & Technol Seoul South Korea 130650 ul 130650, South Korea
Titolo Testata:
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
fascicolo: 1-2, volume: 474, anno: 2001,
pagine: 25 - 33
SICI:
1386-1964(20010301)474:1-2<25:SANOTA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROBLASTOMA SH-SY5Y CELLS; PARKINSONS-DISEASE; L-DOPA; STRAND SCISSION; RAT-BRAIN; SUBSTANTIA-NIGRA; PC12 CELLS; IN-VITRO; 6-HYDROXYDOPAMINE; NEUROTOXIN;
Keywords:
salsolinol; tetrahydroisoquinolines; chromosomal aberrations; comet assay; Chinese hamster lung fibroblasts; redox cycling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Surh, YJ Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea Seoul NatlUniv Seoul South Korea 151742 ul 151742, South Korea
Citazione:
Y.J. Jung et al., "Salsolinol, a naturally occurring tetrahydroisoquinoline alkaloid, inducesDNA damage and chromosomal aberrations in cultured Chinese hamster lung fibroblast cells", MUT RES-F M, 474(1-2), 2001, pp. 25-33

Abstract

Salsolinol (SAL) is a tetrahydroisoquinoline neurotoxin that has been speculated to contribute to pathophysiology of Parkinson's disease and chronic alcoholism. The compound is also found in certain beverages and food stuffs, including soy sauce, beer and bananas. Despite potential human exposure to SAL and its endogenous formation, little is known about the genotoxic or carcinogenic potential of this substance. In the present investigation, SALinduced DNA damage in cultured Chinese hamster lung (CHL) fibroblasts as assessed by single cell gel electrophoresis (Comet). CHL cells treated with SAL also exhibited higher frequencies of chromosomal aberrations than did vehicle-treated controls. Our recent study has revealed that SAL in combination with Cu(II) causes the strand scission in phi X174 supercoiled DNA [Neurosci. Lett. 238 (1997) 95]. In line with this notion, addition of cupric ion potentiated the DNA damaging and clastogenic activity of SAL. Antioxidant vitamins, such as Vitamin C and Vitamin E, and reduced glutathione inhibited clastogenicity of SAL: suggesting the involvement of reactive oxygen species (ROS) in SAL-induced DNA damage and genotoxicity in CHL cells. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:39:02