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Titolo:
Cloning of cDNA for a novel fibrinogen/angiopoietin-related protein, FARP
Autore:
Lee, JH; Seo, JM; Kim, M; Kim, JC;
Indirizzi:
Kyungpook Natl Univ, Sch Med, Dept Immunol, Deagu 700422, South Korea Kyungpook Natl Univ Deagu South Korea 700422 , Deagu 700422, South Korea
Titolo Testata:
MOLECULES AND CELLS
fascicolo: 1, volume: 11, anno: 2001,
pagine: 100 - 104
SICI:
1016-8478(20010228)11:1<100:COCFAN>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-CLONING; FIBRINOGEN-LIKE; COLLAGEN-LIKE; DOMAINS; TIE2; GENE;
Keywords:
angiopoietin; cDNA array; FARP; fibrinogen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, JC Kyungpook Natl Univ, Sch Med, Dept Immunol, Deagu 700422, South Korea Kyungpook Natl Univ Deagu South Korea 700422 700422, South Korea
Citazione:
J.H. Lee et al., "Cloning of cDNA for a novel fibrinogen/angiopoietin-related protein, FARP", MOL CELLS, 11(1), 2001, pp. 100-104

Abstract

Using a low abundant gene screening strategy in the human dermal papilla cell cDNA library, we isolated a novel cDNA? which was 1,872 bp of nucleotides in length and contained an open reading frame encoding 405 amino acids, We designated it 'fibrinogen/angiopoietin-related protein' (FARP) as it contained the characteristic coiled-coil domain and fibrinogen-like domain in the NH2- and COOH-terminal, which are conserved in angiopoietins. FARP has a highly hydrophobic region at the N-terminus that is typical of a secretory signal sequence. Recently, a very similar gene, HFARP, was cloned and they have a difference of only 18 amino acids in N-terminus, While HFARP was expressed only in the liver, northern blot analysis showed that FARP mRNA isabundantly expressed in the liver, placenta, prostate, and ovary in human adult tissues, It was also expressed in the fetal liver and lung carcinoma cell line. Further study will be needed to clarify the function of the FARPgene.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 06:00:15