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Titolo:
Differential expression of oestrogen receptor alpha and beta proteins in the testes and male reproductive system of human and non-human primates
Autore:
Saunders, PTK; Sharpe, RM; Williams, K; Macpherson, S; Urquart, H; Irvine, DS; Millar, MR;
Indirizzi:
MRC, Human Reprod Sci Unit, Edinburgh EH3 9ET, Midlothian, Scotland MRC Edinburgh Midlothian Scotland EH3 9ET h EH3 9ET, Midlothian, Scotland
Titolo Testata:
MOLECULAR HUMAN REPRODUCTION
fascicolo: 3, volume: 7, anno: 2001,
pagine: 227 - 236
SICI:
1360-9947(200103)7:3<227:DEOORA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ESTROGEN-RECEPTOR; RAT TESTIS; ER-BETA; NEONATAL EXPOSURE; EXCURRENT DUCTS; ENVIRONMENTAL ESTROGENS; CELLULAR-LOCALIZATION; TARGETED DISRUPTION; ANDROGEN RECEPTOR; GERM-CELLS;
Keywords:
efferent ductules; epididymis; oestrogen receptor; testis; vas deferens;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Saunders, PTK MRC, Human Reprod Sci Unit, 37 Chalmers St, Edinburgh EH3 9ET, Midlothian,Scotland MRC 37 Chalmers St Edinburgh Midlothian Scotland EH39ET and
Citazione:
P.T.K. Saunders et al., "Differential expression of oestrogen receptor alpha and beta proteins in the testes and male reproductive system of human and non-human primates", MOL HUM REP, 7(3), 2001, pp. 227-236

Abstract

The role(s) oestrogens play in male adult reproductive function remains uncertain. We have used antibodies specific for oestrogen receptor-alpha (ER alpha) and -beta (ERP) to investigate their distribution within the male, In testes from adult human, macaque and marmoset, ER beta protein was detected in Sertoli cells, Leydig cells and peritubular myoid cells. In germ cells, the intensity of immunostaining for ER beta was variable between species, Immunoexpression in preleptotene, leptotene and zygotene spermatocytes was low/absent in all species, Elongated spermatids were consistently immunonegative. No ER alpha immunoexpression was detected in testes, ER beta was detected in epithelial and stromal cell nuclei throughout the male reproductive system [efferent ductules (ED), epididymis, vas deferens, seminal vesicles] and in the bladder, ER alpha was detected in non-ciliated epithelial cells in the ED, but rarely in epithelial and basal cells within the epididymis, Epithelial cells from seminal vesicles and bladder were immunonegativefor ER alpha, Expression of ER alpha in stromal cells was rare in the ED, epididymis and bladder but more frequent in seminal vesicles. Expression ofER alpha, and long and short forms of ER beta, was confirmed by Western blotting. The widespread expression of ER beta suggests that it is the primary target for modulation of tissue function via oestrogenic ligands in the male reproductive system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:34:59