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Titolo:
Effect of vanadium on insulin and leptin in Zucker diabetic fatty rats
Autore:
Wang, J; Yuen, VG; McNeill, JH;
Indirizzi:
Univ British Columbia, Fac Pharmaceut Sci, Div Pharmacol & Toxicol, Vancouver, BC V6T 1Z3, Canada Univ British Columbia Vancouver BC Canada V6T 1Z3 ver, BC V6T 1Z3, Canada
Titolo Testata:
MOLECULAR AND CELLULAR BIOCHEMISTRY
fascicolo: 1-2, volume: 218, anno: 2001,
pagine: 93 - 96
SICI:
0300-8177(200102)218:1-2<93:EOVOIA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA LEPTIN; OBESE GENE; MESSENGER-RNA; BODY-WEIGHT; BIS(MALTOLATO)OXOVANADIUM(IV); ADIPOCYTES; EXPRESSION; SULFATE;
Keywords:
vanadium; leptin; insulin; body fat; Type 2 diabetes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: McNeill, JH Univ British Columbia, Fac Pharmaceut Sci, Div Pharmacol & Toxicol, 2146 EMall, Vancouver, BC V6T 1Z3, Canada Univ British Columbia 2146 E Mall Vancouver BC Canada V6T 1Z3
Citazione:
J. Wang et al., "Effect of vanadium on insulin and leptin in Zucker diabetic fatty rats", MOL C BIOCH, 218(1-2), 2001, pp. 93-96

Abstract

Vanadium exhibits a variety of insulin-mimetic actions in vitro and in vivo. The mechanism(s) of the effect of vanadium on leptin in Zucker diabetic fatty (ZDF) rats, a model of Type 2 diabetes, is unclear. Since insulin is a stimulator of leptin production and secretion and vanadium is an insulin-mimetic or insulin-enhancing agent, we studied how vanadium affected plasmaleptin levels in vivo and the relationship between plasma insulin, leptin and body fat in ZDF rats. Zucker lean and ZDF rats at 9-week old were chronically treated with bis(ethylmaltolato)oxovanadium(IV) (BEOV), an organic vanadium compound, by oral gavage daily for 3 weeks. At termination, the total body fat was weighed and blood was collected for insulin, leptin and glucose assay. BEOV treatment (0.1 mmol/kg/day) significantly decreased plasmaglucose levels in ZDF rats and did not change food intake and body fat content either in lean or ZDF rats. Following 3-week treatment, plasma insulinand leptin levels in BEOV treated ZDF rats were significantly higher, 1.5 and 0.5 fold than untreated rats, respectively. The correlation coefficients in ZDF rats showed that plasma leptin levels were correlated to plasma insulin levels, but not to body fat. These data indicate that plasma leptin levels parallel plasma insulin levels, and the effects of vanadium on leptinappear to be mediated by insulin in ZDF rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 13:06:27