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Titolo:
Pulmonary collectins and innate host defense of the lung
Autore:
LeVine, AM; Whitsett, JA;
Indirizzi:
Childrens Hosp, Med Ctr, Div Neonatol & Pulm Biol, Cincinnati, OH 45229 USA Childrens Hosp Cincinnati OH USA 45229 ulm Biol, Cincinnati, OH 45229 USA
Titolo Testata:
MICROBES AND INFECTION
fascicolo: 2, volume: 3, anno: 2001,
pagine: 161 - 166
SICI:
1286-4579(200102)3:2<161:PCAIHD>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURFACTANT PROTEIN-A; RESPIRATORY SYNCYTIAL VIRUS; GRAM-NEGATIVE BACTERIA; ALVEOLAR MACROPHAGES; PSEUDOMONAS-AERUGINOSA; IN-VIVO; MYCOBACTERIUM-TUBERCULOSIS; PNEUMOCYSTIS-CARINII; DEFICIENT MICE; PHAGOCYTOSIS;
Keywords:
surfactant protein A; surfactant protein D; collectins; host defense;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Whitsett, JA Childrens Hosp, Med Ctr, Div Neonatol & Pulm Biol, 3333 Burnet Ave, Cincinnati, OH 45229 USA Childrens Hosp 3333 Burnet Ave Cincinnati OH USA 45229 29 USA
Citazione:
A.M. LeVine e J.A. Whitsett, "Pulmonary collectins and innate host defense of the lung", MICROBES IN, 3(2), 2001, pp. 161-166

Abstract

Surfactant proteins A and D (SP-A and SP-D) are members of the collectin family of Polypeptides expressed in the respiratory tract that bind bacterial, fungal and viral pathogens, enhancing their opsonization and killing by phagocytic cells. Clearance of bacterial pathogens including group B streptococci, Haemophilus influenza, Pseudomonas aeruginosa and viral pathogens, respiratory syncytial virus, adenovirus and influenza A virus, was deficient in SP-A(-/-) mice. SP-A deficiency was associated with enhanced inflammation and synthesis of proinflammatory cytokines. SP-D-/- mice cleared these bacteria as efficiently as wild-type mice; however, clearance of viral pathogens was deficient in SP-D-/- mice and associated with increased inflammation. SP-A and SP-D play critical and distinct roles in the regulation of alveolar macrophage function and inflammation, contributing to innate defenseof the lung. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:27:34