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Titolo:
The function of scavenger receptors expressed by macrophages and their role in the regulation of inflammation
Autore:
Peiser, L; Gordon, S;
Indirizzi:
Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England Univ Oxford Oxford England OX1 3RE n Sch Pathol, Oxford OX1 3RE, England
Titolo Testata:
MICROBES AND INFECTION
fascicolo: 2, volume: 3, anno: 2001,
pagine: 149 - 159
SICI:
1286-4579(200102)3:2<149:TFOSRE>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; FOAM CELL-FORMATION; GLYCATION END-PRODUCTS; CYSTEINE-RICH DOMAIN; SMOOTH-MUSCLE CELLS; APOPTOTIC CELLS; CLASS-A; IN-VIVO; SR-BI; HOST-DEFENSE;
Keywords:
scavenger receptor; LPS; inflammation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
110
Recensione:
Indirizzi per estratti:
Indirizzo: Peiser, L Univ Oxford, Sir William Dunn Sch Pathol, S Parks Rd, Oxford OX13RE, England Univ Oxford S Parks Rd Oxford England OX1 3RE OX1 3RE, England
Citazione:
L. Peiser e S. Gordon, "The function of scavenger receptors expressed by macrophages and their role in the regulation of inflammation", MICROBES IN, 3(2), 2001, pp. 149-159

Abstract

Macrophages are able to recognise and internalise apoptotic and foreign cells from the tissue microenvironment and, where pertinent, initiate inflammation and macrophage activation. Regulation of this protective response is important so as to prevent inappropriate activation of host cells and excessive tissue damage. Scavenger receptors (SRs) are widely expressed by macrophages and are able to bind a diverse array of endogenous and foreign molecules. Studies have concentrated on the role of the receptors in atherosclerosis as they can endocytose modified lipoproteins, however, this review will detail the accumulating evidence that SRs function in innate immunity andmacrophage control during inflammation. (C) 2001 Editions scientifiques etmedicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 07:26:50