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Titolo:
Postprandial lipemia and associated metabolic disturbances in healthy and hyperlipemic postmenopausal women
Autore:
Pirro, M; Lupattelli, G; Siepi, D; Palumbo, B; Roscini, AR; Marchesi, S; Schillaci, G; Mannarino, E;
Indirizzi:
Univ Perugia, Unit Internal Med Angiol & Arteriosclerosis, Dept Clin & Expt Med, I-06122 Perugia, Italy Univ Perugia Perugia Italy I-06122 in & Expt Med, I-06122 Perugia, Italy
Titolo Testata:
METABOLISM-CLINICAL AND EXPERIMENTAL
fascicolo: 3, volume: 50, anno: 2001,
pagine: 330 - 334
SICI:
0026-0495(200103)50:3<330:PLAAMD>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; TRIGLYCERIDE-RICH LIPOPROTEINS; LOW-DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE; LIPID-METABOLISM; HEART-DISEASE; CHYLOMICRON REMNANTS; MEN; HYPERTRIGLYCERIDEMIA; MENOPAUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Pirro, M Univ Perugia, Unit Internal Med Angiol & Arteriosclerosis, Dept Clin & Expt Med, Via Brunacci Brunamonti 2, I-06122 Perugia, Italy Univ Perugia Via Brunacci Brunamonti 2 Perugia Italy I-06122 aly
Citazione:
M. Pirro et al., "Postprandial lipemia and associated metabolic disturbances in healthy and hyperlipemic postmenopausal women", METABOLISM, 50(3), 2001, pp. 330-334

Abstract

The increased risk for coronary artery disease observed in postmenopausal women is partly explained by a more atherogenic fasting lipoprotein profile. Moreover, natural menopause has been associated with an altered postprandial lipid profile. To better characterize the interaction between fasting and postprandial lipid profile after menopause, we examined postprandial changes in several lipid parameters in three age-matched groups of postmenopausal women (16 affected by mixed hyperlipemia, 17 by common hypercholesterolemia. and 17 normolipemic), who underwent a standardized oral fat-loading test. The magnitude of postprandial lipemia, expressed as 8-hour triglyceride incremental area under the curve, was greater in women with mixed hyperlipemia (1,326 +/- 372 mg (.) dL(-1) (.) h(-1)) than in normal (484 +/- 384 mg (.) dL(-1 .) h(-1)) and hypercholesterolemic (473 +/- 223 mg dL(-1 .) h(-1); both P <.0001) women, and the differences held after adjustment for body mass index and fasting insulin. Women with mixed hyperlipemia showed a significant postprandial decrease in high density lipoprotein 2 (HDL2) cholesterol, lipoprotein (a), and low-density lipoprotein (LDL) particle size. Bath hypercholesterolemic and normolipemic women showed a significant postprandial decrease in HDL cholesterol and lipoprotein (a) levels but not in LDLsize. In a multiple linear regression analysis, fasting triglyceride levels, insulin level, and waist hip ratio were all independent predictors of the magnitude of postprandial lipemia. in conclusion, postmenopausal women with mixed hyperlipemia show a greater postprandial triglyceride increase anda more pronounced reduction in HDL cholesterol level and LDL size than hypercholesterolemic and normolipemic subjects. The presence of the features of insulin resistance syndrome could contribute to the deterioration of postprandial lipemic response in these subjects. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:21:02