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Titolo:
Influence of remnant accumulation markers on plasma concentrations of two lipoprotein(a) subspecies (containing or free of apoE)
Autore:
Bach-Ngohou, K; Giraud, F; Krempf, M; Bard, JM;
Indirizzi:
UFR Pharm, Lab Biochim Fondamentale & Appl, Nantes, France UFR Pharm Nantes France Lab Biochim Fondamentale & Appl, Nantes, France Hotel Dieu, CHU, Ctr Rech Nutr Himaine, Lab Nutr EA 1160, Nantes, France Hotel Dieu Nantes France Nutr Himaine, Lab Nutr EA 1160, Nantes, France Hotel Dieu, CHU, Clin Endocrinol Malad Metab & Nutr, Nantes, France Hotel Dieu Nantes France Endocrinol Malad Metab & Nutr, Nantes, France Inst Sante Ouest, Carquefou, France Inst Sante Ouest Carquefou FranceInst Sante Ouest, Carquefou, France
Titolo Testata:
METABOLISM-CLINICAL AND EXPERIMENTAL
fascicolo: 3, volume: 50, anno: 2001,
pagine: 277 - 282
SICI:
0026-0495(200103)50:3<277:IORAMO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
B-CONTAINING LIPOPROTEINS; APOLIPOPROTEIN-B; MYOCARDIAL-INFARCTION; DIABETES-MELLITUS; RICH LIPOPROTEINS; RISK-FACTORS; LP(A); HYPERTRIGLYCERIDEMIA; PHENOTYPES; SERUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Bard, JM Fac Pharm, Lab Biochim Fondamentale & Appl, 1 Rue Gaston Veil, F-44093 Nantes 1, France Fac Pharm 1 Rue Gaston Veil Nantes France 1 093 Nantes 1, France
Citazione:
K. Bach-Ngohou et al., "Influence of remnant accumulation markers on plasma concentrations of two lipoprotein(a) subspecies (containing or free of apoE)", METABOLISM, 50(3), 2001, pp. 277-282

Abstract

Lipoprotein(a) [Lp(a)], an atherosclerosis marker, has 2 subspecies differing in structure and composition that can easily be distinguished by the presence or absence of apolipoprotein E (apoE). The subspecies containing apoE [Lp(a):B:E] is found mainly in the very-low-density lipoprotein (VLDL) size range, while that free of apoE [Lp(a):B] is found mainly in the LDL size range. As little is known about the physiologic function of these subspecies, this study investigated Lp(a):B and Lp(a):B:E concentrations in a population of normotriglyceridemic and moderately hypertriglyceridemic subjectsin fasting state and attempted to determine the parameters influencing their plasma concentrations. The subjects studied (n = 98) had a mean total Lp(a) concentration of 108 mg/dL (28 to 252, minimum to maximum), a mean Lp(a):B concentration of 92.6 mg/dL (5 to 254), and a mean Lp(a):B:E concentration of 15.6 mg/dL (0 to 137). These results indicate that Lp(a):B:E, even in normolipidemic subjects, constitutes a detectable part of total Lp(a), ie, a mean percentage of 16.2% (0% to 96%). Multiple stepwise regression analyses showed that triacylglycerol has no independent effect on the concentration of Lp(a) subspecies, and that remnant accumulation markers, such as the E/LpB:E molar ratio (number of apoE per particle containing both apoB andapoE) and apoE-LpB (mass of apoE bound to particles containing both apoB and apoE), have a strong independent effect on this concentration. A strong positive influence of E/LpB:E on Lp(a):B:E subspecies was noted, as well asa negative influence of apo E-LpB on Lp(a):B subspecies. Taken together, these results suggest that the apoE bound to LpB:E particles plays a dominant role in the concentration of Lp(a) subspecies and that a redistribution of Lp(a) subspecies occurs under the influence of the apoE content of triacylglycerol-rich lipoprotein particles. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:50:32