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Titolo:
Role of cytokine gene polymorphisms in acute rejection and renal impairment after liver transplantation
Autore:
Jonsson, JR; Hong, C; Purdie, DM; Hawley, C; Isbel, N; Butler, M; Balderson, GA; Clouston, D; Pandeya, N; Stuart, K; Edwards-Smith, C; Crawford, DH; Fawcett, J; Powell, EE;
Indirizzi:
Princess Alexandra Hosp, Dept Gastroenterol & Hepatol, Brisbane, Qld 4102,Australia Princess Alexandra Hosp Brisbane Qld Australia 4102 e, Qld 4102,Australia Univ Queensland, Dept Surg, Brisbane, Qld, Australia Univ Queensland Brisbane Qld Australia pt Surg, Brisbane, Qld, Australia Univ Queensland, Dept Pathol, Brisbane, Qld, Australia Univ Queensland Brisbane Qld Australia Pathol, Brisbane, Qld, Australia Queensland Inst Med Res, Epidemiol & Populat Hlth Unit, Brisbane, Qld 4006, Australia Queensland Inst Med Res Brisbane Qld Australia 4006 , Qld 4006, Australia Princess Alexandra Hosp, Queensland Liver Transplant Serv, Brisbane, Qld 4102, Australia Princess Alexandra Hosp Brisbane Qld Australia 4102 , Qld 4102, Australia Princess Alexandra Hosp, Dept Nephrol, Brisbane, Qld 4102, Australia Princess Alexandra Hosp Brisbane Qld Australia 4102 , Qld 4102, Australia
Titolo Testata:
LIVER TRANSPLANTATION
fascicolo: 3, volume: 7, anno: 2001,
pagine: 255 - 263
SICI:
1527-6465(200103)7:3<255:ROCGPI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; PRIMARY BILIARY-CIRRHOSIS; CHRONIC HEPATITIS-C; TRANSFORMING GROWTH-FACTOR-BETA-1; ALLOGRAFT-REJECTION; TGF-BETA; INTERLEUKIN-10; DISEASE; PROMOTER; ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Powell, EE Princess Alexandra Hosp, Dept Gastroenterol & Hepatol, Ipswich Rd, Brisbane, Qld 4102, Australia Princess Alexandra Hosp Ipswich Rd Brisbane Qld Australia 4102
Citazione:
J.R. Jonsson et al., "Role of cytokine gene polymorphisms in acute rejection and renal impairment after liver transplantation", LIVER TRANS, 7(3), 2001, pp. 255-263

Abstract

Although immunosuppressive regimens are effective, rejection occurs in up to 50% of patients after orthotopic liver transplantation (OLT), and there is concern about side effects from long-term therapy. Knowledge of clinicaland immunogenetic variables may allow tailoring of immunosuppressive therapy to patients according to their potential risks. We studied the association between transforming growth factor-beta, interleukin-10, and tumor necrosis factor alpha (TNF-alpha) gene polymorphisms and graft rejection and renal impairment in 121 white liver transplant recipients. Clinical variables were collected retrospectively, and creatinine clearance was estimated using the formula of Cockcroft and Gault. Biallelic polymorphisms were detectedusing polymerase chain reaction-based methods. Thirty-seven of 121 patients (30.6%) developed at least 1 episode of rejection. Multivariate analysis showed that Child-Pugh score (P =.001), immune-mediated liver disease (P =.018), normal pre-OLT creatinine clearance (P =.037), and fewer HLA class 1 mismatches (P =.038) were independently associated with rejection, Renal impairment occurred in 80% of patients and was moderate or severe in 39%, Clinical variables independently associated with renal impairment were female sex (P =.001), pre-OLT renal dysfunction (P =.0001), and a diagnosis of viral hepatitis (P =.0008), There was a significant difference in the frequency of TNF-alpha -308 alleles among the primary liver diseases. After adjustment for potential confounders and a Bonferroni correction, the association between the TNF-alpha -308 polymorphism and graft rejection approached significance (P =.06). Recipient cytokine genotypes do not have a major independent role in graft rejection or renal impairment after OLT, Additional studies of immunogenetic factors require analysis of large numbers of patients with appropriate phenotypic information to avoid population stratification,which may lead to inappropriate conclusions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/12/19 alle ore 03:58:01