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Titolo:
Prognostic model for early acute rejection after liver transplantation
Autore:
Gomez-Manero, N; Herrero, JI; Quiroga, J; Sangro, B; Pardo, F; Cienfuegos, JA; Prieto, J;
Indirizzi:
Univ Navarra Clin, Liver Unit, Pamplona 31008, Spain Univ Navarra Clin Pamplona Spain 31008 Liver Unit, Pamplona 31008, Spain Univ Navarra Clin, Dept Surg, Pamplona 31008, Spain Univ Navarra Clin Pamplona Spain 31008 Dept Surg, Pamplona 31008, Spain
Titolo Testata:
LIVER TRANSPLANTATION
fascicolo: 3, volume: 7, anno: 2001,
pagine: 246 - 254
SICI:
1527-6465(200103)7:3<246:PMFEAR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC ALLOGRAFT-REJECTION; GRAFT-SURVIVAL; INFECTION; RECIPIENTS; IMMUNITY; IMPACT; IMPAIRMENT; DIAGNOSIS; DISEASE; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Herrero, JI Univ Navarra Clin, Liver Unit, Av Pio XII S-N, Pamplona 31008,Spain Univ Navarra Clin Av Pio XII S-N Pamplona Spain 31008 , Spain
Citazione:
N. Gomez-Manero et al., "Prognostic model for early acute rejection after liver transplantation", LIVER TRANS, 7(3), 2001, pp. 246-254

Abstract

Hepatic graft rejection is a common complication after liver transplantation (LT), with a maximum incidence within the first weeks, The identification of high-risk patients for early acute rejection (EAR) might be useful forclinicians. A series of 133 liver graft recipients treated with calcineurin inhibitors was retrospectively assessed to identify predisposing factors for EAR and develop a mathematica model to predict the individual risk of each patient. The incidence of EAR (less than or equal to 45 days after LT) was 35.3%. Multivariate analysis showed that recipient age, underlying liver disease, and Child's cf ass before LT were independently associated with the development of EAR. Combining these 3 variables, the following risk score for the development of EAR was obtained: EAR score EF(x)] = 2.44 + (1.14x hepatitis C virus cirrhosis) + (2.78 x immunologic cirrhosis) + (2.51 x metabolic cirrhosis) (0.08 x recipient age in years) + (1.65 x Child's class). Risk for rejection = e(F(x))/1 + e(F(x)). The combination of age, causeof liver disease, and Child's class may allow us to predict the risk for EAR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/02/20 alle ore 21:12:15