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Titolo:
Immune activation is required for the induction of liver allograft tolerance: Implications for immunosuppressive therapy
Autore:
Bishop, GA; McCaughan, GW;
Indirizzi:
Royal Prince Alfred Hosp, Centenary Inst, AW Morrow Gastroenterol & Liver Lab, Sydney, NSW, Australia Royal Prince Alfred Hosp Sydney NSW Australiaab, Sydney, NSW, Australia
Titolo Testata:
LIVER TRANSPLANTATION
fascicolo: 3, volume: 7, anno: 2001,
pagine: 161 - 172
SICI:
1527-6465(200103)7:3<161:IAIRFT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL APOPTOSIS; RAT-LIVER; TRANSPLANTATION TOLERANCE; PASSENGER LEUKOCYTES; DENDRITIC CELLS; CLASS-I; ORGAN ALLOGRAFTS; HEART ALLOGRAFTS; GRAFT-SURVIVAL; PERIPHERAL TOLERANCE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
96
Recensione:
Indirizzi per estratti:
Indirizzo: McCaughan, GW Centenary Inst, Locked Bag 6, Newtown, NSW 2042, Australia Centenary Inst Locked Bag 6 Newtown NSW Australia 2042 ralia
Citazione:
G.A. Bishop e G.W. McCaughan, "Immune activation is required for the induction of liver allograft tolerance: Implications for immunosuppressive therapy", LIVER TRANS, 7(3), 2001, pp. 161-172

Abstract

Liver transplants in many animal models are unusual because often they arenot rejected even when transplanted across complete major histocompatibility complex barriers without immunosuppression. Their paradoxical behavior is even more obvious when the immune mechanism of acceptance is examined. Instead of acceptance resulting from a lack of immune response to the graft, the opposite occurs, and there is an unusual extensive increase in immune activation in acceptance compared with rejection. This abnormal extensive immune activation is driven by donor leukocytes transferred with the liver and results in death of the recipient cells that would normally reject the transplant. Some forms of immunosuppression inhibit this activation-associated liver transplant tolerance. The significance of these findings and possible means to design future treatment protocols for clinical transplantation that optimize management of liver transplant recipients are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 14:28:34