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Titolo:
Renal tubular acidosis in horses (1980-1999)
Autore:
Aleman, MR; Kuesis, B; Schott, HC; Carlson, GP;
Indirizzi:
Univ Calif Davis, Sch Vet Med, Dept Med & Epidemiol, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Med & Epidemiol, Davis, CA 95616 USA Elgin Large Anim Med Ctr, Elgin, IL USA Elgin Large Anim Med Ctr Elgin ILUSA Large Anim Med Ctr, Elgin, IL USA Michigan State Univ, Vet Teaching Hosp, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 Hosp, E Lansing, MI 48824 USA
Titolo Testata:
JOURNAL OF VETERINARY INTERNAL MEDICINE
fascicolo: 2, volume: 15, anno: 2001,
pagine: 136 - 143
SICI:
0891-6640(200103/04)15:2<136:RTAIH(>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRIMETHOPRIM-SULFAMETHOXAZOLE; METABOLIC-ACIDOSIS; 2 HORSES; DIAGNOSIS; HYPERCALCEMIA; UROLITHIASIS; EXCRETION; AMMONIUM; HEALTHY; THERAPY;
Keywords:
hyperchloremic metabolic acidosis; renal disease; sodium bicarbonate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Carlson, GP Univ Calif Davis, Sch Vet Med, Dept Med & Epidemiol, Davis, CA95616 USA Univ Calif Davis Davis CA USA 95616 miol, Davis, CA 95616 USA
Citazione:
M.R. Aleman et al., "Renal tubular acidosis in horses (1980-1999)", J VET INT M, 15(2), 2001, pp. 136-143

Abstract

Renal tubular acidosis (RTA) is characterized by altered renal tubular function resulting in hyperchloremic metabolic acidosis. The purpose of the study was to describe RTA in 16 horses. No breed or sex predilection was found. The mean age at onset of the disease was 7 years of age. The type of diet had no apparent effect on development of RTA. The most common clinical signs were depression. poor performance, weight loss, and anorexia. Initial blood work revealed a marked hyperchloremic metabolic acidosis in all horsesand a compensatory respiratory response in most horses. Sixty-three percent (10/16) of the horses had some evidence of renal damage or disease. Initial treatment consisted of large amounts of sodium bicarbonate given intravenously and orally for the prompt correction of the acidosis. Response to treatment was largely dependent on the rate of sodium bicarbonate administration. Long-term oral supplementation with NaHCO3 was required for the maintenance of normal acid-base status in individual horses. Recurrence of RTA was noted in 56% (9/16) of the horses. Horses with evidence of renal disease had multiple relapses. RTA should be considered as a differential diagnosisin horses with vague signs of depression, weight loss, and anorexia. The pathogenesis of RTA in horses remains uncertain. but prompt recognition and early aggressive intravenous sodium bicarbonate therapy followed by long-term oral supplementation seem to be important to successful management.

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Documento generato il 19/01/20 alle ore 09:29:57