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Titolo:
Alterations of K-ras and p53 mutations in colorectal cancer patients in Central Europe
Autore:
Konig, EA; Koves, I; Rasinariu, A; Popp, AR; Kusser, WC; Soyonki, K; Kovacs, A; Glickman, BW; Jeney, A; Marcsek, ZL;
Indirizzi:
Jozsef Fodor Natl Ctr Publ Hlth, Natl Inst Chem Safety, Dept Mol & Cell Biol, H-1450 Budapest, Hungary Jozsef Fodor Natl Ctr Publ Hlth Budapest Hungary H-1450 udapest, Hungary Hungarian Acad Sci, Dept Mol Genet, Budapest, Hungary Hungarian Acad Sci Budapest Hungary , Dept Mol Genet, Budapest, Hungary Semmelweis Univ Med, Fac Med, Inst Pathol & Expt Canc Res 1, Budapest, Hungary Semmelweis Univ Med Budapest Hungary Expt Canc Res 1, Budapest, Hungary Univ Victoria, Ctr Environm Hlth, Dept Biol, Victoria, BC V8W 2Y2, Canada Univ Victoria Victoria BC Canada V8W 2Y2 ol, Victoria, BC V8W 2Y2, Canada Natl Inst Oncol, Dept Surg, Budapest, Hungary Natl Inst Oncol Budapest Hungary st Oncol, Dept Surg, Budapest, Hungary Inst Oncol I Chiricuta, Dept Pathol & Biochem, Cluj Napoca, Romania Inst Oncol I Chiricuta Cluj Napoca Romania iochem, Cluj Napoca, Romania Univ Victoria, Ctr Environm Hlth, Dept Biol, Victoria, BC V8W 2Y2, Canada Univ Victoria Victoria BC Canada V8W 2Y2 ol, Victoria, BC V8W 2Y2, Canada Peterffy Sandor Hosp, Budapest, Hungary Peterffy Sandor Hosp Budapest Hungary fy Sandor Hosp, Budapest, Hungary Semmelweis Univ Med, Fac Med, Inst Pathol & Expt Canc Res 1, Budapest, Hungary Semmelweis Univ Med Budapest Hungary Expt Canc Res 1, Budapest, Hungary
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
fascicolo: 5, volume: 62, anno: 2001,
pagine: 333 - 347
SICI:
1528-7394(20010309)62:5<333:AOKAPM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENE; P21 TRANSFORMING PROTEIN; MURINE SARCOMA-VIRUS; ABERRANT CRYPT FOCI; NUCLEOTIDE-SEQUENCE; POINT MUTATIONS; GASTRIC CANCERS; SSCP ANALYSIS; CARCINOMA; CODON-13;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Marcsek, ZL Jozsef Fodor Natl Ctr Publ Hlth, Natl Inst Chem Safety, Dept Mol & Cell Biol, POB 36, H-1450 Budapest, Hungary Jozsef Fodor Natl Ctr PublHlth POB 36 Budapest Hungary H-1450
Citazione:
E.A. Konig et al., "Alterations of K-ras and p53 mutations in colorectal cancer patients in Central Europe", J TOX E H A, 62(5), 2001, pp. 333-347

Abstract

Many molecular investigations of colorectal cancer (CRC) have suggested that the accumulation of specific mutations in proto-oncogenes and tumor suppressor genes regulating cell growth via signal transduction trigger the stagewise progression to malignancy. In this study, the frequency, location, and type of mutations of the K-ras proto-onco gene exon 1 and p53 tumor suppressor gene exons 5-8 were analyzed in colorectal carcinomas of 65 patientsfrom Central Europe, using polymerase chain reaction (PCR)-cold single-strand conformation polymorphism (SSCP) screening and direct sequencing. The incidence of K-ras activating mutations in these Central European samples was lower (25%) compared to that obtained in American and western European populations (40-50% at least), while the incidence of p53 inactivating mutations was similar (58%). These results suggest that some other genetically linked mechanisms may play a role in CRC development and progression, and hence K-ras and p53 mutations cannot be considered to be universal genetic markers for CRC.

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Documento generato il 17/02/20 alle ore 17:24:24