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Titolo:
Investigation of preference for nightly triazolam versus placebo in moderate social alcohol drinkers
Autore:
Mintzer, MZ; Allen, RP; Griffiths, RR;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Behav Biol Res Ctr, Baltimore, MD 21224 USA Johns Hopkins Univ Baltimore MD USA 21224 es Ctr, Baltimore, MD 21224 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21224 USA Johns Hopkins Univ Baltimore MD USA 21224 Neurol, Baltimore, MD 21224 USA Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21224 USA Johns Hopkins Univ Baltimore MD USA 21224 urosci, Baltimore, MD 21224 USA
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 15, anno: 2001,
pagine: 3 - 8
SICI:
0269-8811(2001)15:1<3:IOPFNT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENZODIAZEPINE USE; REBOUND INSOMNIA; CHRONIC PAIN; DIAZEPAM; HYPNOTICS; MEMORY; RISK; VOLUNTEERS; HUMANS; ABUSE;
Keywords:
benzodiazepine; human; hypnotic; reinforcement; triazolam;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Griffiths, RR Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Behav Biol Res Ctr, 5510 Nathan Shock Dr, Baltimore, MD 21224 USA Johns HopkinsUniv 5510 Nathan Shock Dr Baltimore MD USA 21224
Citazione:
M.Z. Mintzer et al., "Investigation of preference for nightly triazolam versus placebo in moderate social alcohol drinkers", J PSYCHOPH, 15(1), 2001, pp. 3-8

Abstract

This study was designed to examine whether the widely prescribed benzodiazepine hypnotic triazolam has reinforcing effects in moderate social alcoholdrinkers, without histories of drug abuse or insomnia, in the context of its use as a hypnotic. Eleven healthy adult volunteers who met criteria for 'good sleepers' participated in a 60-session double-blind choice study which was conducted on an outpatient basis with participants sleeping at home. Twenty three-session sampling/choice tests were conducted sequentially to provide 20 evaluations of the reinforcing effects of 0.25 mg/70 kg triazolamversus placebo, ingested orally 30 min before bedtime. Each three-session test consisted of two sampling sessions, in which participants received exposure to each of the two drug conditions in different colored capsules, followed by one choice session, in which participants were asked to choose oneof the two colour-coded capsules for self-administration. Four participants exhibited a significant choice of triazolam, three, a significant choice of placebo (i.e. triazolam avoidance), and four, a random (i.e. non-significant) choice between triazolam and placebo. The reasons provided by participants were consistent with their choices and with the expected effects of triazolam versus placebo. Analyses of post-sleep questionnaires indicated that triazolam did not produce a clinically meaningful improvement in sleep. The finding that triazolam functioned as a reinforcer in participants without insomnia suggests that triazolam has reinforcing effects in some individuals for which hypnotic treatment is not clinically indicated, and that health care professionals must continue to assess the risk/benefit ratio of benzodiazepine hypnotic prescription.

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Documento generato il 29/03/20 alle ore 11:33:11