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Titolo:
Evidence of a substantial genetic basis for risk of adult periodontitis
Autore:
Michalowicz, BS; Diehl, SR; Gunsolley, JC; Sparks, BS; Brooks, CN; Koertge, TE; Califano, JV; Burmeister, JA; Schenkein, HA;
Indirizzi:
Univ Minnesota, Sch Dent, Dept Prevent Sci, Minneapolis, MN 55455 USA UnivMinnesota Minneapolis MN USA 55455 nt Sci, Minneapolis, MN 55455 USA Natl Inst Dent & Craniofacial Res, Craniofacial Epidemiol & Genet Branch, Bethesda, MD USA Natl Inst Dent & Craniofacial Res Bethesda MD USA anch, Bethesda, MD USA Virginia Commonwealth Univ, Sch Dent, Clin Res Ctr Periodontal Dis, Richmond, VA USA Virginia Commonwealth Univ Richmond VA USA odontal Dis, Richmond, VA USA Univ Maryland, Sch Dent, Dept Periodont, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 t Periodont, Baltimore, MD 21201 USA
Titolo Testata:
JOURNAL OF PERIODONTOLOGY
fascicolo: 11, volume: 71, anno: 2000,
pagine: 1699 - 1707
SICI:
0022-3492(200011)71:11<1699:EOASGB>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
EARLY-ONSET PERIODONTITIS; DWELLING OLDER ADULTS; TWIN DATA; ATTACHMENT LOSS; DISEASE; VARIANCE; GENOTYPE; ZYGOSITY;
Keywords:
disease susceptibility; diseases in twins; twins; periodontitis/etiology; periodontitis/genetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Michalowicz, BS 7-368 Moos Tower,515 Delaware St SE, Minneapolis, MN 55455USA 7-368 Moos Tower,515 Delaware St SE Minneapolis MN USA 55455
Citazione:
B.S. Michalowicz et al., "Evidence of a substantial genetic basis for risk of adult periodontitis", J PERIODONT, 71(11), 2000, pp. 1699-1707

Abstract

Background: A few previous studies have suggested that risk for adult periodontitis (AP) has a genetic (heritable) component. We estimated genetic and environmental variances and heritability for gingivitis and adult periodontitis using data from twins reared together. Methods: One hundred seventeen (117) pairs of adult twins (64 monozygotic [MZ] and 53 dizygotic [DZ] pairs) were recruited. Probing depth (PD), attachment loss (AL), plaque, and gingivitis (GI) were assessed on all teeth by two examiners. Measurements were averaged over all sites, teeth, and examiners. Extent of disease in subjects was defined at four thresholds: the percentage of teeth with AL greater than or equal to2, AL greater than or equalto3, PD greater than or equal to4, or PD greater than or equal to5 mm. Genetic and environmental variances and heritability were estimated using pathmodels with maximum likelihood estimation techniques. Results: MZ twins were more similar than DZ twins for all clinical measures. Statistically significant genetic variance was found for both the severity and extent of disease. AP was estimated to have approximately 50% heritability, which was unaltered following adjustments for behavioral variables including smoking. In contrast, while MZ twins were also more similar than DZ twins for gingivitis scores, there was no evidence of heritability for gingivitis after behavioral covariates such as utilization of dental care and smoking were incorporated into the analyses. Conclusions: These results confirm previous studies and indicate that approximately half of the variance in disease in the population is attributed to genetic variance. The basis for the heritability of periodontitis appearsto be biological and not behavioral in nature.

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Documento generato il 05/12/20 alle ore 23:50:06