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Titolo:
Human herpesviruses and Porphyromonas gingivalis are associated with juvenile periodontitis
Autore:
Michalowicz, BS; Ronderos, M; Camara-Silva, R; Contreras, A; Slots, J;
Indirizzi:
Univ Minnesota, Sch Dent, Dept Prevent Sci, Minneapolis, MN 55455 USA UnivMinnesota Minneapolis MN USA 55455 nt Sci, Minneapolis, MN 55455 USA Univ So Calif, Sch Dent, Dept Periodontol, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 odontol, Los Angeles, CA 90089 USA Univ Valle, Dept Periodontol, Cali, Colombia Univ Valle Cali ColombiaUniv Valle, Dept Periodontol, Cali, Colombia
Titolo Testata:
JOURNAL OF PERIODONTOLOGY
fascicolo: 6, volume: 71, anno: 2000,
pagine: 981 - 988
SICI:
0022-3492(200006)71:6<981:HHAPGA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
EARLY-ONSET PERIODONTITIS; HUMAN-IMMUNODEFICIENCY-VIRUS; POLYMERASE CHAIN-REACTION; EPSTEIN-BARR-VIRUS; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; CYTOMEGALOVIRUS-INFECTION; MOLECULAR EPIDEMIOLOGY; ADULT PERIODONTITIS; SUBGINGIVAL PLAQUE; EPITHELIAL-CELLS;
Keywords:
dental plague/microbiology; periodontitis; juvenile/microbiology; clinical trials, controlled; cytomegalovirus; Epstein-Barr virus; herpesvirus; Jamaica;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Michalowicz, BS 7-368 Moos Tower,515 Delaware St SE, Minneapolis, MN 55455USA 7-368 Moos Tower,515 Delaware St SE Minneapolis MN USA 55455
Citazione:
B.S. Michalowicz et al., "Human herpesviruses and Porphyromonas gingivalis are associated with juvenile periodontitis", J PERIODONT, 71(6), 2000, pp. 981-988

Abstract

Background: Although herpesviruses have been associated with adult periodontitis, their relationship with juvenile periodontitis (JP) has not been established. This case-control study examined possible associations between JP and pathogenic bacteria, the human cytomegalovirus (HCMV), and the Epstein-Barr type 1 virus (EBV-1). Methods: Subjects were participants in a larger survey of schoolchildren in North-Central Jamaica. Subgingival plaque samples from 15 subjects with JP, 20 with incipient periodontitis (IP), and 65 randomly-selected healthy controls were assayed for Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans using a 16S rRNA polymerase chain reaction (PCR) identification method, and for HCMV and EBV-1 using nested PCR identification. Results: Strong bivariate associations were found between JP and P. gingivalis (odds ratio [OR] = 12.7; 95% CI = 2.6, 61.4), HCMV (OR = 10.0; 95% CI = 2.7, 36.3), and A. actinomycetemcomitans (OR = 8.0; 95% CI = 2.3, 27.5), but not EBV-1. In multivariate analyses, P. gingivalis remained a significant explanatory variable (OR = 7.8; 95% CI = 1.5, 40.9); however, the associations were marginal for HCMV (OR = 4.6; 95% CI = 0.9, 22.7), and non-significant for A. actinomycetemcomitans (OR = 2.0; 95% CI = 0.4, 9.7). The associations with JP and the extent of attachment loss were even stronger when both P. gingivalis and HCMV were detected together. P. gingivalis (OR = 3.9; 95% CI = 1.3, 12.0) and EBV-1 (OR = 3.3; 95% CI = 1.0, 10.3) were the only significant explanatory variables in the multivariate analysis of 1P. Conclusions: P. gingivalis is the strongest and most stable indicator of periodontitis in Jamaican adolescents. Co-infection with P. gingivalis and HCMV appears to be particularly deleterious to periodontal health.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 12:49:27