Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Autoimmune thyroid disease in Indian children with type 1 diabetes mellitus
Autore:
Menon, PSN; Vaidyanathan, B; Kaur, M;
Indirizzi:
All India Inst Med Sci, Dept Pediat, Genet Unit, Div Pediat Endocrinol & Genet, New Delhi 110029, India All India Inst Med Sci New Delhi India 110029 t, New Delhi 110029, India
Titolo Testata:
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
fascicolo: 3, volume: 14, anno: 2001,
pagine: 279 - 286
SICI:
0334-018X(200103)14:3<279:ATDIIC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HASHIMOTOS-THYROIDITIS; AUTOANTIBODIES; PEROXIDASE; IDDM; ADOLESCENTS; PREVALENCE; ANTIBODIES;
Keywords:
antithyroid antibodies; autoimmune thyroid disease; Hashimoto's thyroiditis; thyroid; thyroid peroxidase antibody; thyroglobulin antibody; type 1 diabetes mellitus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Menon, PSN All India Inst Med Sci, Dept Pediat, Genet Unit, Div Pediat Endocrinol & Genet, New Delhi 110029, India All India Inst Med Sci New DelhiIndia 110029 i 110029, India
Citazione:
P.S.N. Menon et al., "Autoimmune thyroid disease in Indian children with type 1 diabetes mellitus", J PED END M, 14(3), 2001, pp. 279-286

Abstract

The objective of the present study was to determine the prevalence of autoimmune thyroid disease in Indian children with type 1 diabetes mellitus by the assay of antibodies to thyroid peroxidase and thyroglobulin. The study population consisted of 35 children with type 1 diabetes mellitus and 32 healthy age- and sex-matched control children. Thyroid peroxidase antibodies (TPO) were determined by ELISA and thyroglobulin antibodies (TGA) by passive hemagglutination. Thyroid function tests and tests of glycemic control were also performed. These assays were repeated after six months and one year. TPO were observed in 19 (54.3%) patients compared to three (10%) controls, and TGA in 11 (31.4%) patients and none of the controls, Both these observations were statistically significant with p=0.0002 for TPO and 0.0016 forTGA, The prevalence of these antibodies was not different in boys and girls and did not change with the duration of diabetes. All patients who were positive for TGA were also positive for TPO. Thyroid function tests were abnormal in one patient who was found to have Hashimoto's thyroiditis. There is a definite need to screen all diabetic children for thyroid antibodies and carefully follow up those patients in whom these antibodies are positive.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 13:52:40