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Titolo:
New thoughts on female precocious puberty
Autore:
Ojeda, SR; Heger, S;
Indirizzi:
Oregon Hlth Sci Univ, Oregon Reg Primate Res Ctr, Div Neurosci, Beaverton,OR 97006 USA Oregon Hlth Sci Univ Beaverton OR USA 97006 rosci, Beaverton,OR 97006 USA
Titolo Testata:
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
fascicolo: 3, volume: 14, anno: 2001,
pagine: 245 - 256
SICI:
0334-018X(200103)14:3<245:NTOFPP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-RELEASING HORMONE; GAMMA-AMINOBUTYRIC-ACID; D-ASPARTATE RECEPTORS; LUTEINIZING-HORMONE; RHESUS-MONKEYS; GROWTH-FACTOR; HYPOTHALAMIC HAMARTOMAS; NEUROENDOCRINE CONTROL; KAINATE RECEPTORS; ANGELMAN-SYNDROME;
Keywords:
female sexual precocity; hypothalamus; neurotransmitters; astroglial cells; growth factors; neuron-glia communication; gonadotropin hormone releasing hormone;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Ojeda, SR Oregon Hlth Sci Univ, Oregon Reg Primate Res Ctr, Div Neurosci, 505 NW 185th Ave, Beaverton, OR 97006 USA Oregon Hlth Sci Univ 505 NW 185thAve Beaverton OR USA 97006 USA
Citazione:
S.R. Ojeda e S. Heger, "New thoughts on female precocious puberty", J PED END M, 14(3), 2001, pp. 245-256

Abstract

Much effort has been devoted in recent years to unravel the neuroendocrinemechanisms responsible for the initiation of mammalian puberty. The concept that has emerged is that puberty results from the unfolding of a centrally originated process involving the concerted influence of neuronal systems that utilize excitatory and inhibitory amino acids as transmitters and astroglial networks: that produce growth factors able to affect LHRH secretion. We discuss the idea that an isolated alteration of each of these components may result in the precocious activation of pulsatile LHRH release, and thus lead to idiopathic sexual precocity. According to this notion, such a premature activation of LHRH neuronal function would be neither associated with structural damage of the neuroendocrine brain system, nor related to a generalized activation of the neuronal-glial mechanisms underlying the onsetof puberty. On the contrary, localized activation of discrete cellular subsets functionally connected to LHRH neurons would suffice to promote an increase in LHRH release of sufficient magnitude and duration to initiate the pubertal process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:31:47