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Titolo:
Dobutamine stress electrocardiography-gated Tc-99m tetrofosmin SPECT for detection of viable but dysfunctional myocardium
Autore:
Yamagishi, H; Akiola, K; Hirata, K; Sakanoue, Y; Toda, I; Yoshiyama, M; Teragaki, M; Takeuchi, K; Yoshikawa, J; Ochi, H;
Indirizzi:
Osaka City Univ, Sch Med, Dept Internal Med 1, Abeno Ku, Osaka 5458586, Japan Osaka City Univ Osaka Japan 5458586 ed 1, Abeno Ku, Osaka 5458586, Japan Osaka City Univ, Sch Med, Div Nucl Med, Abeno Ku, Osaka 5458586, Japan Osaka City Univ Osaka Japan 5458586 Med, Abeno Ku, Osaka 5458586, Japan
Titolo Testata:
JOURNAL OF NUCLEAR CARDIOLOGY
fascicolo: 1, volume: 8, anno: 2001,
pagine: 58 - 66
SICI:
1071-3581(200101/02)8:1<58:DSETTS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; POSITRON-EMISSION-TOMOGRAPHY; LEFT-VENTRICULAR DYSFUNCTION; HIBERNATING MYOCARDIUM; COMPUTED-TOMOGRAPHY; F-18 FLUORODEOXYGLUCOSE; THROMBOLYTIC THERAPY; FUNCTIONAL RECOVERY; EJECTION FRACTION; PERFUSION SPECT;
Keywords:
dobutamine; myocardial viability; tetrofosmin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Yamagishi, H Osaka City Univ, Sch Med, Dept Internal Med 1, Abeno Ku, 1-5-7 Asahi Machi, Osaka 5458586, Japan Osaka City Univ 1-5-7 Asahi Machi Osaka Japan 5458586 Japan
Citazione:
H. Yamagishi et al., "Dobutamine stress electrocardiography-gated Tc-99m tetrofosmin SPECT for detection of viable but dysfunctional myocardium", J NUCL CARD, 8(1), 2001, pp. 58-66

Abstract

Background. Technetium-99m-labeled myocardial perfusion tracers allow simultaneous assessment of myocardial perfusion and left ventricular function by electrocardiography-gated scan. This study was performed to determine whether dobutamine stress electrocardiography-gated tetrofosmin single photon emission computed tomography (SPECT) can identify viable (as defined by positron emission tomography [PET]) but dysfunctional myocardium with contractile reserve. Methods and Results. Thirty-five patients with myocardial infarction underwent resting electrocardiography-gated SPECT and fluorodeoxyglucose (FDG) PET. The relative uptakes of tetrofosmin (% tetrofosmin) and FDG (% FDG) were calculated. Wall motion in 9 left ventricular segments was assessed at rest and during dobutamine stress on a 3-dimensional cine-mode display created,vith automatic left ventricular function analysis software. A total of 129 dysfunctional segments were analyzed. Forty-five (48.9 %) of 92 segments with % tetrofosmin of 50 % or greater and only 4 (10.8%) of 37 segments with % tetrofosmin less than 50% had contractile reserves (P < .0001). The sensitivity, specificity, and predictive accuracy of % tetrofosmin of 50 % or greater for detecting % FDG of 50% or greater were 85,7%, 74%, and 82.9%, respectively. The incidence of the presence of contractile reserve rose withincreasing magnitude of % FDG. The sensitivity, specificity, and predictive accuracy of the presence of contractile reserve for detecting % FDG of 50% or greater were 43.9 %, 80.6 % and 52.7 %, respectively. Conclusions. Dobutamine stress electrocardiography-gated SPECT can identify viable (as defined by PET) but dysfunctional myocardium with contractile reserve.

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Documento generato il 20/06/19 alle ore 17:25:25