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Titolo:
Domain interactions regulating AMPA receptor desensitization
Autore:
Partin, KM;
Indirizzi:
Colorado State Univ, Dept Anat & Neurobiol, Ft Collins, CO 80523 USA Colorado State Univ Ft Collins CO USA 80523 iol, Ft Collins, CO 80523 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 6, volume: 21, anno: 2001,
pagine: 1939 - 1948
SICI:
0270-6474(20010315)21:6<1939:DIRARD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIGAND-BINDING DOMAIN; D-ASPARTATE RECEPTOR; GLUTAMATE RECEPTORS; ALLOSTERIC MODULATION; ACTIVATION; PROTEIN; CHANNEL;
Keywords:
AMPA receptors; glutamate receptors; cyclothiazide; desensitization; electrophysiology; ion channels; mutagenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Partin, KM Colorado State Univ, Dept Anat & Neurobiol, Ft Collins, CO 80523 USA Colorado State Univ Ft Collins CO USA 80523 lins, CO 80523 USA
Citazione:
K.M. Partin, "Domain interactions regulating AMPA receptor desensitization", J NEUROSC, 21(6), 2001, pp. 1939-1948

Abstract

Desensitization is a common property of glutamate and other ligand-gated ion channels, yet its molecular mechanism is unknown. For glutamate receptors, agonist binding involves interactions with identified amino acids from two lobes and may result in stabilizing the lobes in a closed "clamshell" conformation. The present studies demonstrate that two structures, beta -strands 7 and 8 and alpha -helices J and K, functionally interact with each other and likely form hinges between the two lobes, influencing the coupling between agonist binding and desensitization. Two amino acids identified within these regions form a solvent-exposed interface with a third amino acid, a mutation of which was shown previously to block receptor desensitization (L-507 in glutamate receptor 3). This interface may regulate a concerted conformational shift of the AMPA subtype of glutamate receptor subunits to the desensitized state.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 18:09:13