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Titolo:
The amygdala is essential for the development of neuronal plasticity in the medial geniculate nucleus during auditory fear conditioning in rats
Autore:
Maren, S; Yap, SA; Goosens, KA;
Indirizzi:
Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ept Psychol, Ann Arbor, MI 48109 USA Univ Michigan, Program Neurosci, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 am Neurosci, Ann Arbor, MI 48109 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 6, volume: 21, anno: 2001,
pagine: NIL_1 - NIL_6
SICI:
0270-6474(20010315)21:6<NIL_1:TAIEFT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; BASOLATERAL AMYGDALA; LATERAL AMYGDALA; SPIKE TRAINS; MEMORY; LESIONS; CORTEX; COMPONENTS; RESPONSES; THALAMUS;
Keywords:
thalamus; basolateral amygdala; single unit; neuronal plasticity; fear conditioning; freezing; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Maren, S Univ Michigan, Dept Psychol, 525 E Univ Ave, Ann Arbor, MI 48109 USA Univ Michigan 525 E Univ Ave Ann Arbor MI USA 48109 MI 48109 USA
Citazione:
S. Maren et al., "The amygdala is essential for the development of neuronal plasticity in the medial geniculate nucleus during auditory fear conditioning in rats", J NEUROSC, 21(6), 2001, pp. NIL_1-NIL_6

Abstract

The medial geniculate nucleus of the thalamus (MGN) and the basolateral complex of the amygdala (BLA) are critical components of the neural circuit that mediates auditory fear conditioning. Several studies indicate that neurons in both the MGN and BLA exhibit associative plasticity of spike firing during auditory fear conditioning. In the present study, we examined whether the development of plasticity in the MGN requires the BLA. Single units were recorded from chronic multichannel electrodes implanted in the medial division of the MGN of conscious and freely moving rats. Rats received auditory fear conditioning trials, which consisted of a white-noise conditional stimulus (CS) and a co-terminating footshock unconditional stimulus (US). Unpaired (sensitization) controls received the same number of trials as paired animals, but the CS and US were explicitly unpaired. Before fear conditioning, rats received either an intra-amygdala infusion of muscimol, a GABA(A) receptor agonist, to inactivate BLA neurons or an infusion of the salinevehicle. Auditory fear conditioning produced a substantial increase in both CS-elicited spike firing in the MGN and conditional freezing behavior in vehicle-treated rats receiving paired training. Muscimol inactivation of the BLA severely attenuated the development of both conditioning-related increases in CS-elicited spike firing in the MGN and conditional freezing to the auditory CS. Unpaired training did not yield increases in either CS-elicited spike firing or freezing to the tone CS. These results reveal that the BLA is essential to the development of plasticity in the auditory thalamus during fear conditioning.

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Documento generato il 04/04/20 alle ore 02:35:03