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Titolo:
Tumor regression induced by intratumoral injection of DNA coding for humaninterleukin 12 into melanoma metastases in gray horses
Autore:
Heinzerling, LM; Feige, K; Rieder, S; Akens, MK; Dummer, R; Stranzinger, G; Moelling, K;
Indirizzi:
Univ Zurich, Inst Med Virol, CH-8028 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8028 irol, CH-8028 Zurich, Switzerland Vet Univ Hosp Zurich, Dept Large Anim Internal Med, CH-8057 Zurich, Switzerland Vet Univ Hosp Zurich Zurich Switzerland CH-8057 8057 Zurich, Switzerland Swiss Fed Inst Technol, Dept Anim Sci, CH-8092 Zurich, Switzerland Swiss Fed Inst Technol Zurich Switzerland CH-8092 92 Zurich, Switzerland Univ Zurich, Sch Med, Dept Dermatol, CH-8091 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8091 atol, CH-8091 Zurich, Switzerland
Titolo Testata:
JOURNAL OF MOLECULAR MEDICINE-JMM
fascicolo: 12, volume: 78, anno: 2001,
pagine: 692 - 702
SICI:
0946-2716(2001)78:12<692:TRIBII>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTE MATURATION FACTOR; INTRAMUSCULAR GENE-TRANSFER; NAKED PLASMID DNA; IN-VIVO; IMMUNE-RESPONSES; ANTITUMOR IMMUNITY; LIPOSOME COMPLEXES; NUDE-MICE; THERAPY; VACCINE;
Keywords:
large animal; melanoma model; plasmid DNA treatment; species specificity; cytokine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Moelling, K Univ Zurich, Inst Med Virol, Gloriastr 30, CH-8028 Zurich, Switzerland Univ Zurich Gloriastr 30 Zurich Switzerland CH-8028 itzerland
Citazione:
L.M. Heinzerling et al., "Tumor regression induced by intratumoral injection of DNA coding for humaninterleukin 12 into melanoma metastases in gray horses", J MOL MED-J, 78(12), 2001, pp. 692-702

Abstract

Preclinical studies investigating new therapeutic principles against melanoma are presently being carried out in mouse models; however, these are notoptimal. Here we describe a novel animal model using gray horses. These animals spontaneously develop metastatic melanoma that resembles human disease and is thus highly relevant for preclinical studies testing new immunotherapy protocols. We found that injection of plasmid DNA coding for the humancytokine interleukin 12 into established metastases induced significant regression in all 12 treated lesions in a total of 7 horses. Complete disappearance was observed in one treated lesion, with no recurrence after 6 months. No adverse events have been observed in any of the animals during and after treatment. These results demonstrate the effectiveness and safety of interleukin 12 encoding plasmid DNA therapy against established metastatic disease in a large animal model and serve as a basis for a clinical trial.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:38:39