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Titolo:
Distribution of D-amino-acid oxidase and D-serine in vertebrate brains
Autore:
Horiike, K; Ishida, T; Tanaka, H; Arai, R;
Indirizzi:
Shiga Univ Med Sci, Dept Biochem, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci Otsu Shiga Japan 5202192 m, Otsu, Shiga 5202192, Japan Fujita Hlth Univ, Sch Med, Dept Anat, Toyoake, Aichi 4701192, Japan FujitaHlth Univ Toyoake Aichi Japan 4701192 oyoake, Aichi 4701192, Japan
Titolo Testata:
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
fascicolo: 1-6, volume: 12, anno: 2001,
pagine: 37 - 41
SICI:
1381-1177(20010228)12:1-6<37:DODOAD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; D-ASPARTATE; D-ALANINE; CRYSTAL-STRUCTURE; D-PROLINE; MOUSE; LOCALIZATION; INVOLVEMENT; CEREBELLUM; ASTROCYTES;
Keywords:
D-amino-acid oxidase; D-amino acid; D-serine; astrocytes; vertebrate; brain; NMDA receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Horiike, K Shiga Univ Med Sci, Dept Biochem, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci Otsu Shiga Japan 5202192 iga 5202192, Japan
Citazione:
K. Horiike et al., "Distribution of D-amino-acid oxidase and D-serine in vertebrate brains", J MOL CAT B, 12(1-6), 2001, pp. 37-41

Abstract

In mammalian brains, D-amino-acid oxidase activity is absent or scarce in the forebrain, is confined to the brain stem and cerebellum. and its localization is extended to the spinal cord. The oxidase-containing cells are astrocytes including Bergmann glial cells. Neither neurons, endothelial cells,oligodendrocytes nor ependymal cells show the oxidase activity. Free D-serine, a potent activator of the N-methyl-D-aspartate (NMDA) receptor, is in high levels in the forebrain (ca. 0.4 mu mol/g wet weight), and in low levels in the hindbrain. Thus, the localization of the oxidase activity is inversely correlated with the distribution of D-serine in mammalian brains. This inverse correlation is generally found in vertebrate brains. These results indicate that D-amino-acid oxidase decomposes D-amino acids including D-serine in vertebrate brains, and that the magnitude of its activity is important in determining the regional concentrations of D-amino acids in the steady states. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:16:24