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Titolo:
Sleep-disordered breathing and glucose metabolism in hypertensive men: a population-based study
Autore:
Elmasry, A; Lindberg, E; Berne, C; Janson, C; Gislason, T; Tageldin, MA; Boman, G;
Indirizzi:
Univ Uppsala, Akad Sjukhuset, Dept Med Sci Resp Med & Allergol, S-75185 Uppsala, Sweden Univ Uppsala Uppsala Sweden S-75185 & Allergol, S-75185 Uppsala, Sweden Ain Shams Univ, Dept Chest Dis, Cairo, Egypt Ain Shams Univ Cairo EgyptAin Shams Univ, Dept Chest Dis, Cairo, Egypt Univ Uppsala, Akad Sjukhuset, Dept Med Sci, S-75185 Uppsala, Sweden Univ Uppsala Uppsala Sweden S-75185 ept Med Sci, S-75185 Uppsala, Sweden Vifilsstadir Hosp, Dept Lung Med, Gardabaer, Iceland Vifilsstadir Hosp Gardabaer Iceland , Dept Lung Med, Gardabaer, Iceland
Titolo Testata:
JOURNAL OF INTERNAL MEDICINE
fascicolo: 2, volume: 249, anno: 2001,
pagine: 153 - 161
SICI:
0954-6820(200102)249:2<153:SBAGMI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR RISK-FACTORS; 10-YEAR FOLLOW-UP; DIABETES-MELLITUS; APNEA SYNDROME; INSULIN-RESISTANCE; FAT DISTRIBUTION; WEIGHT-GAIN; OBESITY; EXERCISE; HYPOXIA;
Keywords:
diabetes; hypertension; sleep apnoea;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Lindberg, E Univ Uppsala, Akad Sjukhuset, Dept Med Sci Resp Med & Allergol, S-75185 Uppsala, Sweden Univ Uppsala Uppsala Sweden S-75185 S-75185 Uppsala, Sweden
Citazione:
A. Elmasry et al., "Sleep-disordered breathing and glucose metabolism in hypertensive men: a population-based study", J INTERN M, 249(2), 2001, pp. 153-161

Abstract

Objectives. Diabetes mellitus and obstructive sleep apnoea (OSA) are two prevalent medical problems. Both are strongly associated with obesity and hypertension. The aim of this study was to investigate whether the association between OSA and diabetes is entirely dependent on obesity in hypertensivemen. Design. A population-based study. Setting. The municipality of Uppsala, Sweden. Subjects and methods. In 1994, 2668 men aged 40-79 years answered a questionnaire regarding snoring, sleep disturbances and somatic diseases. An age-stratified sample of 116 hypertensive men was selected for a whole-night sleep study. Twenty-five of them had diabetes, defined as reporting regular medical controls for diabetes or having a fasting blood glucose greater thanor equal to6.1 mmol L-1. Results. The prevalence of severe OSA, defined as apnoea-hypopnoea index (AHI) greater than or equal to 20 h(-1) was significantly higher in diabeticpatients than in normoglycaemic subjects (36 vs. 14.5%, P < 0.05). The sample was divided into four groups based on the presence or absence of severeOSA and the presence or absence of central obesity, defined as waist-to-hip ratio (WHR) <greater than or equal to>1.0. In a logistic regression modelwith the non-OSA, WHR <1.0 as the reference group, the adjusted odds ratio(95% confidence interval) for diabetes was 11.8 (2.0-69.8) in the OSA, WHR<greater than or equal to>1.0 group, whilst it was 3.6 (0.9-14.8) in the non-OSA, WHR greater than or equal to1.0 group and 5.7 (0.3-112) in the OSA,WHR <1.0 group. In a linear regression model, after adjustment for WHR, there was a significant relationship between variables of sleep-disordered breathing and fasting insulin, glucose and haemoglobin Ale. Conclusions. We conclude that, in hypertensive men, although obesity is the main risk factor for diabetes, coexistent severe OSA may add to this risk. Sleep breathing disorders, independent of central obesity, may influence plasma insulin and glycaemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 04:08:35