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Titolo:
Differential expression of leukocyte receptor complex-encoded Ig-like receptors correlates with the transition from effector to memory CTL
Autore:
Young, NT; Uhrberg, M; Phillips, JH; Lanier, LL; Parham, P;
Indirizzi:
Stanford Univ, Sch Med, Dept Struct Biol, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 t Struct Biol, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 iol & Immunol, Stanford, CA 94305 USA DNAX Res Inst Mol & Cellular Biol Inc, Palo Alto, CA 94306 USA DNAX Res Inst Mol & Cellular Biol Inc Palo Alto CA USA 94306 CA 94306 USA
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 6, volume: 166, anno: 2001,
pagine: 3933 - 3941
SICI:
0022-1767(20010315)166:6<3933:DEOLRC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; CD8(+) T-CELLS; INHIBITORY RECEPTORS; LYMPHOKINE PRODUCTION; MYELOID CELLS; CUTTING EDGE; LYMPHOCYTES; MOLECULES; FAMILY; CD94/NKG2A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Young, NT Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg, Oxford OX39DU, England Univ Oxford Oxford England OX3 9DU rg, Oxford OX3 9DU, England
Citazione:
N.T. Young et al., "Differential expression of leukocyte receptor complex-encoded Ig-like receptors correlates with the transition from effector to memory CTL", J IMMUNOL, 166(6), 2001, pp. 3933-3941

Abstract

human leukocyte receptor complex (LRC) on chromosome 19q13.4 encodes Ig superfamily receptors expressed on hemopoietic cells, Killer Ig-like receptors (KIR) are expressed in cytotoxic lymphocytes but other LRC molecules (Ig-like transcript(ILT)leukocyte Ig-like receptor (LIR)) are more ubiquitous. We investigated expression of the ILT2/LIR1 inhibitory receptor compared with the related KIR, Both ILT2/LIR1 and KIR were expressed by peripheral CD8(+) T cells with a memory/effector phenotype. ILT2/LIR1(+) T cells demonstrated diverse TCRBV repertoires in contrast to KIR+ T cells, while numbers of peripheral ILT2/LIR1(+) T cells were greater than KIR+ T cells and the majority of ILT2/LIR1(+) T cells did not coexpress KIR, Analysis of CD8(+) T cells with specific HLA class I tetramers confirmed this pattern of expression, indicating differential regulation of LRC gene expression in T lymphocytes, Only a minor proportion of TLT2/LIR1(+) KIR- clones survived in vitrocloning, were more susceptible to anti-CD3 or cognate peptide induced celldeath than KIR+ T cells and exhibited lower levels of the Bcl-2 survival molecule. Our results indicate a sequential program of LRC-encoded receptor expression with initial ILT2/LIR1 expression in effector T cells and KIR gene transcription in the minor proportion of expanded clones which survives activation-induced cell death to become long term memory T cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 22:20:14