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Titolo:
IL-30 is required for regulatory T cells to mediate tolerance to alloantigens in vivo
Autore:
Hara, M; Kingsley, CI; Niimi, M; Read, S; Turvey, SE; Bushell, AR; Morris, PJ; Powrie, F; Wood, KJ;
Indirizzi:
Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg, Oxford OX3 9DU, England Univ Oxford Oxford England OX3 9DU ld Dept Surg, Oxford OX3 9DU, England
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 6, volume: 166, anno: 2001,
pagine: 3789 - 3796
SICI:
0022-1767(20010315)166:6<3789:IIRFRT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC ALLOGRAFT SURVIVAL; GROWTH-FACTOR-BETA; ANTI-CD4 MONOCLONAL-ANTIBODY; TRANSPLANTATION TOLERANCE; INTESTINAL INFLAMMATION; IN-VIVO; LYMPHOKINE PRODUCTION; INFECTIOUS TOLERANCE; IMMUNE REGULATION; CLONAL ANERGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Wood, KJ Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg, Oxford OX3 9DU, England Univ Oxford Oxford England OX3 9DU urg, Oxford OX3 9DU, England
Citazione:
M. Hara et al., "IL-30 is required for regulatory T cells to mediate tolerance to alloantigens in vivo", J IMMUNOL, 166(6), 2001, pp. 3789-3796

Abstract

We present evidence that donor-reactive CD4+ T cells present in mice tolerant to donor alloantigens are phenotypically and functionally heterogeneous. CD4+ T cells contained within the CD45RB(high) fraction remained capable of mediating graft rejection when transferred to donor alloantigen-grafted T cell-depleted mice. In contrast, the CD54RB(low) CD4(+) and CD25(+)CD4(+)populations failed to induce rejection, but rather, were able to inhibit rejection initiated by naive CD45RB(high) CD4(+) T cells, Analysis of the mechanism of immunoregulation transferred by CD45RB(low) CD4(+) T cells in vivo revealed that it was donor Ag specific and could be inhibited by neutralizing Abs reactive with IL-10, but not IL-4, CD45RB(low) CD4(+) T cells from tolerant mice were also immune suppressive in vitro, as coculture of these cells with naive CD45RB(high) CD4(+) T cells inhibited proliferation and Th1 cytokine production in response to donor alloantigens presented via theindirect pathway. These results demonstrate that alloantigen-specific regulatory T cells contained within the CD45RB(low) CD4(+) T cell population are responsible for the maintenance of tolerance to donor alloantigens in vivo and require IL-10 for functional activity.

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Documento generato il 01/04/20 alle ore 17:54:41