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Titolo:
Cutting edge: Human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis
Autore:
Altincicek, B; Moll, J; Campos, N; Foerster, G; Beck, E; Hoeffler, JF; Grosdemange-Billiard, C; Rodriguez-Concepcion, M; Rohmer, M; Boronat, A; Eberl, M; Jomaa, H;
Indirizzi:
Univ Giessen, Inst Biochem, D-35392 Giessen, Germany Univ Giessen Giessen Germany D-35392 t Biochem, D-35392 Giessen, Germany Joman Pharmaka GmbH, Giessen, Germany Joman Pharmaka GmbH Giessen Germany man Pharmaka GmbH, Giessen, Germany Univ Barcelona, Dept Bioquim & Biol Mol, Barcelona, Spain Univ Barcelona Barcelona Spain ept Bioquim & Biol Mol, Barcelona, Spain Univ Strasbourg 1, Inst Le Bel, CNRS, F-67070 Strasbourg, France Univ Strasbourg 1 Strasbourg France F-67070 , F-67070 Strasbourg, France
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 6, volume: 166, anno: 2001,
pagine: 3655 - 3658
SICI:
0022-1767(20010315)166:6<3655:CEHGDT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE; ESCHERICHIA-COLI; NONMEVALONATE PATHWAY; ISOPENTENYL DIPHOSPHATE; PERIPHERAL-BLOOD; 4-(CYTIDINE 5'-DIPHOSPHO)-2-C-METHYL-D-ERYTHRITOL; MYCOBACTERIUM-TUBERCULOSIS; PSEUDOMONAS-AERUGINOSA; NONPEPTIDE ANTIGENS; LYMPHOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Altincicek, B Univ Giessen, Inst Biochem, Friedrichstr 24, D-35392 Giessen, Germany Univ Giessen Friedrichstr 24 Giessen Germany D-35392 ermany
Citazione:
B. Altincicek et al., "Cutting edge: Human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis", J IMMUNOL, 166(6), 2001, pp. 3655-3658

Abstract

Activation of V gamma9/V delta2 T cells by small nonprotein Ags is frequently observed after infection with various viruses, bacteria, and eukaryoticparasites. We suggested earlier that compounds synthesized by the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway of isopentenyl pyrophosphate synthesis are responsible for the V gamma9/V delta2 T cell reactivity of many pathogens. Using genetically engineered Escherichia coli knockout strains, we now demonstrate that the ability of E. coli extracts to stimulate gamma delta T cell proliferation is abrogated when genes coding for essential enzymes of the MEP pathway, dxr or gcpE, are disrupted or deleted from the bacterial genome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 18:52:39