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Titolo:
A common mutation of low-density lipoprotein receptor gene is associated with essential hypertension among Japanese
Autore:
Fu, Y; Katsuya, T; Higaki, J; Asai, T; Fukuda, M; Takiuchi, S; Hatanaka, Y; Rakugi, H; Ogihara, T;
Indirizzi:
Osaka Univ, Grad Sch Med, Dept Geriatr Med, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 atr Med, Suita, Osaka 5650871, Japan
Titolo Testata:
JOURNAL OF HUMAN HYPERTENSION
fascicolo: 2, volume: 15, anno: 2001,
pagine: 125 - 130
SICI:
0950-9240(200102)15:2<125:ACMOLL>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BLOOD-PRESSURE; FAMILIAL HYPERCHOLESTEROLEMIA; MOLECULAR-GENETICS; PLASMA-LIPIDS; ALPHA-ADDUCIN; POLYMORPHISMS; LOCUS; DETERMINANTS; EXPRESSION; VARIANT;
Keywords:
lipid metabolism; single nucleotide polymorphism (SNP); restriction fragment polymorphism (RFLP); genetics; genetic susceptibility;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Higaki, J Osaka Univ, Grad Sch Med, Dept Geriatr Med, 2-2 B6 Yamadaoka, Suita, Osaka5650871, Japan Osaka Univ 2-2 B6 Yamadaoka Suita Osaka Japan 5650871 871, Japan
Citazione:
Y. Fu et al., "A common mutation of low-density lipoprotein receptor gene is associated with essential hypertension among Japanese", J HUM HYPER, 15(2), 2001, pp. 125-130

Abstract

Candidate genes offer one approach to the identification of the genetic susceptibility to hypertension, A common gene variant of the low-density lipoprotein (LDL) receptor gene (LDLR) that affects plasma LDL metabolism within the normolipidaemic range, may be such a candidate gene, A common mutation of LDLR, C1773T, was associated with lipid metabolism such that the T1773allele increased plasma LDL levels in a Caucasian population. The present study examined whether C1773T/LDLR was associated with essential hypertension in a Japanese population. Subjects with essential hypertension (EHT, n =300) with a family history of hypertension, and controls (NT, n = 310, sex- and age-matched with EHT) were recruited from among outpatients at Osaka University Hospital. A C1773T substitution at codon 570 in LDLR was determined using PCR- Hinc II-RFLP. It was revealed that the C1773 allele was significantly more frequent (0.89) among hypertensive patients (X-2 = 9.58, P <0.01) than normotensives (0.83), the calculated odds ratio being 1.7 (95% CI: 1.2-2.4). The effect of the T1773 allele on increasing cholesterol was significant in normotensives without antihyperlipidaemic medication, but not in hypertensives. After adjustments of confounding factors, the estimatedodds ratio for hypertension in the subjects with C1773 homozygote increased to 2.1 (95% CI: 1.3-3.5), suggesting that this polymorphism is an independent risk factor for hypertension. Our results show that the C1773 mutant of LDLR increases susceptibility to hypertension, but not via hypercholesterolaemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 01:30:43