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Titolo:
Polymorphisms of the renin-angiotensin system in patients with multifocal renal arterial fibromuscular dysplasia
Autore:
Bofinger, A; Hawley, C; Fisher, P; Daunt, N; Stowasser, M; Gordon, R;
Indirizzi:
Univ Queensland, Dept Med, Greenslopes Private Hosp, Hypertens Unit, Brisbane, Qld 4120, Australia Univ Queensland Brisbane Qld Australia 4120 Brisbane, Qld 4120, Australia
Titolo Testata:
JOURNAL OF HUMAN HYPERTENSION
fascicolo: 3, volume: 15, anno: 2001,
pagine: 185 - 190
SICI:
0950-9240(200103)15:3<185:POTRSI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING-ENZYME GENE; SERIAL INTRAVASCULAR ULTRASOUND; INSERTION DELETION POLYMORPHISM; MAJOR RISK FACTOR; CORONARY ANGIOPLASTY; RENOVASCULAR HYPERTENSION; HORMONE REPLACEMENT; NEOINTIMA FORMATION; STENT RESTENOSIS; VASCULAR INJURY;
Keywords:
fibromuscular dysplasia; renin-angiotensin system; renovascular hypertension; renal artery; gene polymorphisms; aetiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Gordon, R Univ Queensland, Dept Med, Greenslopes Private Hosp, Hypertens Unit, Newdegate St, Brisbane, Qld 4120, Australia Univ Queensland Newdegate St Brisbane Qld Australia 4120 stralia
Citazione:
A. Bofinger et al., "Polymorphisms of the renin-angiotensin system in patients with multifocal renal arterial fibromuscular dysplasia", J HUM HYPER, 15(3), 2001, pp. 185-190

Abstract

Fibromuscular dysplasia (FMD) is an important cause of renal artery stenosis, particularly in young females. Polymorphisms of the renin-angiotensin (RA) system have been implicated in the pathogenesis of hypertension and atherosclerotic vascular disease, and may play a role in the development of FMD. Examination of polymorphisms by PCR for angiotensin-converting enzyme (ACE) I/D, angiotensin II type 1 receptor (AT(1)R) A1166C and angiotensinogen(AGT) M235T and T174M was undertaken in 43 patients with typical multifocal renal arterial FMD (MF-FMD) and in 89 controls. The age of NIF-FMD patients at the time of diagnosis of hypertension did not differ (38.6 + 11.1 years vs 35.5 +/- 10.3 years, P = 0.12) from controls and the proportion (95% vs 86%, P = 0.14) of females was similar. Allele frequencies did not differsignificantly between groups, except that MF-FMD patients had a significantly higher frequency of the ACE I allele than control subjects (0.62 vs 0.47, P = 0.026). Since the ACE I allele is associated with lower circulating ACE levels and possibly lower tissue levels of angiotensin II (Ang II), andsince Ang II modulates vascular smooth muscle cell growth and synthetic activity, the I allele might predispose to defective remodelling of the arterial media, and thus to the development of MF-FMD. This contrasts with atherosclerotic renal artery stenosis, coronary stent restenosis and carotid intimal thickening, which are diseases affecting the arterial intima, and which are associated with increased frequency of the D allele.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:39:42