Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Dietary cholesterol does not normalize low plasma cholesterol levels but induces hyperbilirubinemia and hypercholanemia in Mdr2 P-glycoprotein-deficient mice
Autore:
Voshol, PJ; Koopen, NR; de Vree, JML; Havinga, R; Princen, HMG; Elferink, RPJO; Groen, AK; Kuipers, F;
Indirizzi:
Univ Groningen Hosp, Groningen Univ Inst Drug Explorat, Ctr Liver Digest &Metab Dis, NL-9700 RB Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9700 RB ningen, Netherlands TNO PG, Gaubius Lab, Leiden, Netherlands TNO PG Leiden NetherlandsTNO PG, Gaubius Lab, Leiden, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Gastrointestinal & Liver Dis, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands
Titolo Testata:
JOURNAL OF HEPATOLOGY
fascicolo: 2, volume: 34, anno: 2001,
pagine: 202 - 209
SICI:
0168-8278(200102)34:2<202:DCDNNL>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; BINDING CASSETTE TRANSPORTER-1; SCAVENGER RECEPTOR BI; TANGIER-DISEASE; RAT-LIVER; PRIMARY CULTURE; SR-BI; ACIDS; GENE; HOMEOSTASIS;
Keywords:
high density lipoprotein; phospholipids; bile salts; bilirubin; transgenic mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Kuipers, F Univ Groningen Hosp, Groningen Univ Inst Drug Explorat, Ctr Liver Digest &Metab Dis, CMC 4,Room Y115,Hanzepl 1,POB 30 001, NL-9700 RB Groningen, Netherlands Univ Groningen Hosp CMC 4,Room Y115,Hanzepl 1,POB 30 001Groningen Netherlands NL-9700 RB
Citazione:
P.J. Voshol et al., "Dietary cholesterol does not normalize low plasma cholesterol levels but induces hyperbilirubinemia and hypercholanemia in Mdr2 P-glycoprotein-deficient mice", J HEPATOL, 34(2), 2001, pp. 202-209

Abstract

Background/Aims: Mdr2 P-glycoprotein deficiency in mice (Mdr2((-/-))) leads to formation of cholesterol/cholesterol-depleted bile and reduced plasma HDL cholesterol. We addressed the questions: (1) does HDL in Mdr2((-/-)) mice normalize upon phospholipid and/or cholesterol feeding, and (2): is the Mdr2((-/-)) liver capable of handling excess dietary cholesterol. Methods: Male and female Mdr2((-/-)) and Mdr2((+/+)) mice were fed diets with or without additional phosphatidylcholine and/or cholesterol, Plasma, hepatic and biliary lipids as well as liver function parameters and expression of transport proteins involved in bile formation were analyzed. Results: Feeding excess phospholipids and/or cholesterol did not affect lipoprotein levels in Mdr2((+/+)) or Mdr2((-/+)) mice. Dietary cholesterol caused hyperbilirubinemia (male +100%; female +500%) and elevated plasma bilesalts (male +200 %; female +1250 %) in Mdr2((-/-)) mice only, independent of phospholipids. Bile flow nor biliary bile salt and bilirubin secretion were affected in cholesterol-fed Mdr2((-/-)) mice. Elevated plasma bile salts may be related to cholesterol-induced reduction of hepatic Nac-taurocholate cotransporting protein expression in Mdr2((-/-)) mice. Conclusion: Excess dietary phospholipids and cholesterol do not normalize low HDL associated with Mdr2 P-glycoprotein-deficiency. Induction of hyperbilirubinemia and hypercholanemia by dietary cholesterol in Mdr2((-/-)) micedelineates the important role of biliary lipid secretion in normal hepaticfunctioning. (C) 2001 European Association for the Study of the Liver. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 15:24:32