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Titolo:
Positron emission tomographic measurement of brain acetylcholinesterase activity using N-[C-11]methylpiperidin-4-yl acetate without arterial blood sampling: Methodology of shape analysis and its diagnostic power for Alzheimer's disease
Autore:
Tanaka, N; Fukushi, K; Shinotoh, H; Nagatsuka, S; Namba, H; Iyo, M; Aotsuka, A; Ota, T; Tanada, S; Irie, T;
Indirizzi:
Natl Inst Radiol Sci, Dept Med Imaging, Inage Ku, Chiba 2638555, Japan Natl Inst Radiol Sci Chiba Japan 2638555 Inage Ku, Chiba 2638555, Japan Tokyo Womens Med Coll, Daini Hosp, Dept Neurosurg, Tokyo 162, Japan Tokyo Womens Med Coll Tokyo Japan 162 , Dept Neurosurg, Tokyo 162, Japan Asahi Neurol Hosp, Chiba, Japan Asahi Neurol Hosp Chiba JapanAsahi Neurol Hosp, Chiba, Japan Daichi Pure Chem, ADME TOX Res Inst, Ibaraki, Osaka, Japan Daichi Pure Chem Ibaraki Osaka Japan TOX Res Inst, Ibaraki, Osaka, Japan Hamamatsu Univ, Sch Med, Dept Neurosurg, Shizuoka, Japan Hamamatsu Univ Shizuoka Japan Sch Med, Dept Neurosurg, Shizuoka, Japan Chiba Univ, Sch Med, Dept Psychiat, Chiba 280, Japan Chiba Univ Chiba Japan 280 niv, Sch Med, Dept Psychiat, Chiba 280, Japan Chiba Univ, Sch Med, Dept Neurol, Chiba 280, Japan Chiba Univ Chiba Japan 280 Univ, Sch Med, Dept Neurol, Chiba 280, Japan Juntendo Univ, Sch Med, Dept Psychiat, Tokyo 113, Japan Juntendo Univ Tokyo Japan 113 , Sch Med, Dept Psychiat, Tokyo 113, Japan
Titolo Testata:
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
fascicolo: 3, volume: 21, anno: 2001,
pagine: 295 - 306
SICI:
0271-678X(200103)21:3<295:PETMOB>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; IN-VIVO; BUTYRYLCHOLINESTERASE; CORTEX;
Keywords:
N-[C-11]methylpiperidin-4-yl acetate acetylcholinesterase; positron emission tomography; Alzheimer's disease; shape analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Irie, T Natl Inst Radiol Sci, Dept Med Imaging, Inage Ku, 9-1 Anagawa 4 Chome, Chiba 2638555, Japan Natl Inst Radiol Sci 9-1 Anagawa 4 Chome Chiba Japan 2638555 apan
Citazione:
N. Tanaka et al., "Positron emission tomographic measurement of brain acetylcholinesterase activity using N-[C-11]methylpiperidin-4-yl acetate without arterial blood sampling: Methodology of shape analysis and its diagnostic power for Alzheimer's disease", J CEREBR B, 21(3), 2001, pp. 295-306

Abstract

N-[C-11]methylpiperidin-4-yl acetate ([C-11]MP4A) is a radiotracer that has been used successfully for the quantitative measurement of acetylcholinesterase (AChE) activity in the human brain with positron emission tomography(PET) using a standard compartment model analysis and a metabolite-corrected arterial input function. In the current study, the authors evaluated theapplicability of a simple kinetic analysis without blood sampling, namely shape analysis. First, the authors used computer simulations to analyze factors that affect the precision and bias of shape analysis, then optimized the shape analysis procedure for [C-11]MP IA. Before shape analysis execution, the later part of dynamic PET data except for the initial 3 minutes weresmoothed by fitting to a bi-exponential function followed by linear interpolation of 8 data points between each of adjacent scan frames. Simulations showed that shape analysis yielded estimates of regional metabolic rates of[C-11]MP4A by AChE (k(3)) with acceptable precision and bias in brain regions with low k(3) values such as neocortex. Estimates in regions with higher k(3) values became progressively more inaccurate. The authors then applied the method to [C-11]MP4A PET data in 10 healthy subjects and 20 patients with Alzheimer's disease (AD). There was a highly significant linear correlation in regional k(3) estimates between shape and compartment analyses (300 neocortical regions, [shape k(3)] = 0.93 x [NLS k(3)], r = 0.89, P < 0.001). Significant reductions in k(3) estimates of frontal, temporal, parietal, occipital, and sensorimotor cerebral cortices in patients with AD as compared with controls were observed when using shape analysis (P < 0.013, two-tailed t-test), although these reductions (17% to 20%) were somewhat less than those obtained by compartment analysis (22% to 27%). The sensitivity ofshape analysis for detecting neocortical regions with abnormally low k(3) in the 20 patients with AD (92 out of 200 regions, 46%) also was somewhat less than compartment analysis (136 out of 200 regions, 68%). However, taking its simplicity and noninvasiveness into account, the authors conclude that quantitative measurement of neocortical AChE activity with shape analysisand [C-11]MP4A PET is practical and useful for clinical diagnosis of AD.

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Documento generato il 30/11/20 alle ore 16:52:36