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Titolo:
Frequency of genotypic and phenotypic drug-resistant HIV-1 among therapy-naive patients of the German Seroconverter Study
Autore:
Duwe, S; Brunn, M; Altmann, D; Hamouda, O; Schmidt, B; Walter, H; Pauli, G; Kucherer, C;
Indirizzi:
Robert Koch Inst, D-13353 Berlin, Germany Robert Koch Inst Berlin Germany D-13353 ch Inst, D-13353 Berlin, Germany Free Univ Berlin, Fachbereich Biol, Berlin, Germany Free Univ Berlin Berlin Germany rlin, Fachbereich Biol, Berlin, Germany Univ Erlangen Nurnberg, Natl Referenzzentrum Retroviren, Inst Klin & Mol Virol, Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany & Mol Virol, Erlangen, Germany
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 3, volume: 26, anno: 2001,
pagine: 266 - 273
SICI:
1525-4135(20010301)26:3<266:FOGAPD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-LEVEL RESISTANCE; VIRUS TYPE-1 VARIANTS; IMMUNODEFICIENCY-VIRUS; REVERSE-TRANSCRIPTASE; PROTEASE INHIBITORS; CELL-CULTURE; ZIDOVUDINE; MUTATION; SENSITIVITY; TRANSMISSION;
Keywords:
HIV-1; drug resistance; therapy-naive seroconverter; phenotypic; genotypic; primary resistance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Kucherer, C Robert Koch Inst, Nordufer 20, D-13353 Berlin, Germany Robert Koch Inst Nordufer 20 Berlin Germany D-13353 , Germany
Citazione:
S. Duwe et al., "Frequency of genotypic and phenotypic drug-resistant HIV-1 among therapy-naive patients of the German Seroconverter Study", J ACQ IMM D, 26(3), 2001, pp. 266-273

Abstract

Genotypic and phenotypic resistance of viral reverse transcriptase (RT) and protease (PR) was determined for 64 therapy-naive, HIV-1-infected seroconverters of the German Seroconverter Study coordinated by the Robert Koch-Institut, Berlin. The date of seroconversion of patients: and the laboratory,clinical, and therapeutic follow-up data were documented. Samples were collected between 1996 and 1999. Phenotypic resistant HIV-1 were found in 8 (13%) seroconverters: in most cases resistance was weak and mainly directed against RT inhibitors (4 nucleoside reverse transcriptase inhibitors [NRTIs], 2 nonnucleoside reverse transcriptase inhibitors [NNRTIs], 1 combination NRTI/NNRTI). Only one infection with a weak PR inhibitor resistance was identified. Transmission of multidrug-resistant HIV-1 has not yet been observed. Frequently at least one or more amino acid mutations associated with antiretroviral drug resistance were detected by genotypic analysis. The mean number of resistance-associated mutations in the: RT of the transmitted virus has increased significantly since 1996. Studies have shown the improved benefit of initial antiretroviral therapy if based on genotypic resistance data. In view of the considerably high level of transmission of resistant HIV-1 in Germany, which is also seen in other studies in Europe and the United States, we suggest determining the genotypic resistance pattern before starting therapy of newly HIV-1-infected patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:43:47