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Titolo:
Detection of genetic changes in anal intraepithelial neoplasia (AIN) of HIV-positive and HIV-negative men
Autore:
Haga, T; Kim, SH; Jensen, RH; Darragh, T; Palefsky, JM;
Indirizzi:
Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Stomatol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 3, volume: 26, anno: 2001,
pagine: 256 - 262
SICI:
1525-4135(20010301)26:3<256:DOGCIA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPARATIVE GENOMIC HYBRIDIZATION; HUMAN-PAPILLOMAVIRUS INFECTION; CHROMOSOMAL-ABERRATIONS; RECURRENT PATTERN; HOMOSEXUAL MEN; SOLID TUMORS; BISEXUAL MEN; RISK-FACTORS; IN-SITU; CANCER;
Keywords:
anal intraepithelial neoplasia; anal squamous intraepithelial lesions; human papillomavirus; comparative genomic hybridization; anal cancer; genetic changes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Palefsky, JM Univ Calif San Francisco, Dept Lab Med, 505 Parnassus Ave,Room M1203,Box 0126, San Francisco, CA 94143 USA Univ Calif San Francisco 505 Parnassus Ave,Room M1203,Box 0126 San Francisco CA USA 94143
Citazione:
T. Haga et al., "Detection of genetic changes in anal intraepithelial neoplasia (AIN) of HIV-positive and HIV-negative men", J ACQ IMM D, 26(3), 2001, pp. 256-262

Abstract

Compared with HIV-negative individuals, HIV-positive individuals have a higher prevalence of anogenital human papillomavirus (HPV) infection, as wellas a higher incidence of HPV-associated anal cancer. Little is currently known of chromosomal changes occurring in anal intraepithelial neoplasia (AIN). the probable precursor to anal cancer. Genetic changes in AIN were characterized by comparative genomic hybridization (CGH) in a study of samples:obtained from 19 HIV-positive and 11 HIV-negative men. The proportion withgenetic changes significantly increased with the severity of the histopathologic grade with none diagnosed as (0%) AIN 1; 5 of 17 (29%) as AIN 2; and5 of 9 (56%) AIN 3 showing genetic changes (p = .07). This correlation wasalso found in study subjects who had multiple biopsies with different grades of pathology concurrently or serially over time. The most common regional DNA copy number change was gain mapped to chromosome arm 3q (12% of AIN 2and 33% of AIN 3). This alteration was previously reported to be commonestalteration in cervical cancer, which suggests a common molecular pathway for these two HPV-associated anogenital neoplasias.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:42:57