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Titolo:
Alterations of apolipoprotein B metabolism in HIV-infected patients with antiretroviral combination therapy
Autore:
Schmitz, M; Michl, GM; Walli, R; Bogner, J; Bedynek, A; Seidel, D; Goebel, FD; Demant, T;
Indirizzi:
Inst Klin Chem & Med Poliklin, Dresden, Germany Inst Klin Chem & Med Poliklin Dresden Germany oliklin, Dresden, Germany Univ Munich, Munich, Germany Univ Munich Munich GermanyUniv Munich, Munich, Germany
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 3, volume: 26, anno: 2001,
pagine: 225 - 235
SICI:
1525-4135(20010301)26:3<225:AOABMI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE; HYPERLIPIDEMIA; LIPODYSTROPHY; INHIBITORS; DISEASE; HYPERTRIGLYCERIDEMIA; PATHOGENESIS; SENSITIVITY;
Keywords:
apo B metabolism; kinetic modeling; HIV; protease inhibitors; hypertriglyceridemia; insulin resistance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Demant, T Krankenhaus Dresden Friedrichstadt, Inst Klin Chem & Lab Med, Friedrichstr41, D-01067 Dresden, Germany Krankenhaus Dresden Friedrichstadt Friedrichstr 41 Dresden Germany D-01067
Citazione:
M. Schmitz et al., "Alterations of apolipoprotein B metabolism in HIV-infected patients with antiretroviral combination therapy", J ACQ IMM D, 26(3), 2001, pp. 225-235

Abstract

Background: Dyslipidemia (predominantly hypertriglyceridemia) is frequently seen in patients receiving antiretroviral combination therapy (ART). However, the underlying mechanisms and long-term risks (e.g., cardiovascular events) are still unclear. Objectives/Methods: In 5 patients with ART-associated dyslipidemia, stableisotope labeled amino acid tracer (d3-Leu) kinetic analysis over 12 days was used to investigate the metabolism of apolipoprotein B-containing lipoproteins (very low density lipoproteins [VLDL](1), VLDL2, intermediate density lipoproteins [IDL] and low density lipoproteins [LDL]). Data were compared with those in 6 healthy normolipidemic controls. Results: The patients under ART showed significantly increased fasting triglycerides (359 vs. 77 mg/dl) and VLDL (54 vs. 15 mg/dl), compared with controls. They had significantly higher total cholesterol (213 vs. 157 mg/dl) and then was a nonsignificant trend toward higher LDL (136 vs. 93 mg/dl), and toward lower HDL (26 vs. 46 mg/dl). The ratio of large, buoyant LDL, over small, dense LDL, was markedly reduced in patients under ART (0.80 vs. 2.00). Total apo B synthesis was significantly increased (25.5 vs. 14.5 mg/kg/d) and shifted, toward triglyceride rich VLDL1 (18.5 vs. 8.7 mg/kg/d) in patients receiving ART. There was also a significantly reduced rate of apo Blipoprotein transfer from VLDL1 to VLDL2 (3.7 vs. 20.7 pools/d). In addition, all patients revealed insulin resistance. Conclusions: These data indicate that increased triglycerides in HIV-infected patients with ART are primary due to reduced rates of VLDL transfer into denser lipoproteins implying a lower rate of lipoprotein lipase-mediated delipidation. In addition, total apo B synthesis was increased and shifted toward triglyceride-rich VLDL1. Overall, this lipoprotein profile in patients with ART-associated dyslipidemia implies an increased risk for cardiovascular events.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:05:47